Content, Bioavailability and Health Effects of Trace Elements and Bioactive Components in Organic Agricultural Systems

NCT ID: NCT00738166

Last Updated: 2016-07-29

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 18 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2007-10-31
• Study Completion Date: 2010-12-31

Brief Summary

Trace elements, bioactive secondary metabolites and vitamins are among the most important quality parameters in plants. Yet, very little information is available on their content, bioavailability and health effects of organically grown plant food products. The main objective of the project is to study the impact of different agricultural management practises relevant for organic farming on the ability of cereal and vegetable crops to absorb trace elements from the soil and to synthesise bioactive compounds (secondary metabolites, antioxidant vitamins and phytates) with health promoting effects. Field experiments with a rigidly controlled design will be implemented together with state-of-the-art analytical techniques allowing solid conclusions to be drawn on the variability and optimum levels of bioactive compounds. The multitude of analytical data from plant and soil samples will be analysed by multivariate statistical methods in order to reveal differences between the cultivation systems used. Finally, the relationship between bioavailability of the nutrients studied and the elemental fingerprint of plants will be extracted by the statistical methods.

Conditions

Healthy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Blinding Strategy: DOUBLE

Study Groups

II

organic animal manure

Group Type: EXPERIMENTAL

Organic or conventional diet

Intervention Type: OTHER

12 days on fully controlled organic 1 diet, organic 2 diet and conventional diet

Diet (organic or conventional)

Intervention Type: OTHER

organic or conventional diet

III

conventional

Group Type: ACTIVE_COMPARATOR

Organic or conventional diet

Intervention Type: OTHER

12 days on fully controlled organic 1 diet, organic 2 diet and conventional diet

Diet (organic or conventional)

Intervention Type: OTHER

organic or conventional diet

I

organic green manure

Group Type: EXPERIMENTAL

Organic or conventional diet

Intervention Type: OTHER

12 days on fully controlled organic 1 diet, organic 2 diet and conventional diet

Diet (organic or conventional)

Intervention Type: OTHER

organic or conventional diet

Interventions

Organic or conventional diet

12 days on fully controlled organic 1 diet, organic 2 diet and conventional diet

Intervention Type: OTHER

Diet (organic or conventional)

organic or conventional diet

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Healthy adults aged 18-45 years
• BMI 20-30 kg/m2
• Non-vegetarian

Exclusion Criteria

• Physical activity > 10 h/week
• Intake of dietary supplements
• Regular use of drugs
• Chronic diseases
• Smoking
• Excessive intake of alcohol

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Copenhagen

OTHER

Sponsor Role: lead

Responsible Party

Arne Astrup

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

IHE-LIFE

Frederiksberg, , Denmark

Countries

Denmark

Other Identifiers

M194

Identifier Type: -

Identifier Source: secondary_id

H-C-2007-0078

Identifier Type: -

Identifier Source: org_study_id