Effect of Dexamethasone on Migraine Headache

NCT ID: NCT00733382

Last Updated: 2008-08-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE1

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-02-29

Study Completion Date

2009-08-31

Brief Summary

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Dexamethasone is a safe and cheap abortive therapy for migraine headache. The effect of it is never evaluate and not correlate with the effect of popular anti migraine medication such as dihydroergotamine. The investigators proposal is to compare its effect with dihydroergotamine.

Detailed Description

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Conditions

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Migraine Headache

Keywords

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migraine dexamethasone dihydroergotamine

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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1

Group Type EXPERIMENTAL

dexamethazone

Intervention Type DRUG

injection form, 8 miligram, injected once

2

Group Type ACTIVE_COMPARATOR

dexamethazone

Intervention Type DRUG

injection form, 8 miligram, injected once

Interventions

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dexamethazone

injection form, 8 miligram, injected once

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Migraine attack according to international headache society criteria
2. Migraine without aura; at least 5 attack with mean duration of 4 to 72 hours and 2 of following:

* Unilateral
* Pulsatile
* Severe enough to impair daily activity
* Aggravate with walking and climbing, also 1 of following:

* Nausea and or vomiting
* Photophobia and phonophobia, and not contributed to other headache.
3. Migraine with aura; at least 2 attacks with 3 of following:

* One reversible aura
* Aura became apparent at least in 4 minutes
* Aura not lasting more than 60 minutes
* Headache develops in less than 60 minutes after aura

Exclusion Criteria

1. Hypertension
2. Ischemic heart disease
3. Basilar migraine with sign and symptoms such as:

* Diplopia
* Ataxia
* Dysarthria
* Dysphagia
* Weakness
* Sensory disorder
* Drowsiness
4. Peripheral vascular disease
5. Sepsis
6. Age more than 40 and less than 15 year old
7. Pregnancy
8. Use of triptans and ergots derivatives in past 24 hours
Minimum Eligible Age

15 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shiraz University of Medical Sciences

OTHER

Sponsor Role lead

Responsible Party

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Shiraz university of medical sciences

Locations

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Peyman Petramfar

Shiraz, Fars, Iran

Site Status

Countries

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Iran

Other Identifiers

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212110

Identifier Type: -

Identifier Source: org_study_id