Safety and Efficacy Predimenol for Headache

NCT ID: NCT06558006

Last Updated: 2025-02-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-06-19

Study Completion Date

2024-10-15

Brief Summary

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This is a prospective, double-blind, placebo-controlled and randomized study aimed to obtain a description of the efficacy and safety of Predimenol in alleviating headache.

Detailed Description

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Predimenol is a bioactive fraction extracted from Phaleria macrocarpa pericarpium (Mahkota Dewa).

There will be 20 subjects per group (a total of 60 subjects) planned to be enrolled in the study.

The investigational drug: tablet @200 mg of Predimenol. Dose administration: one singe dose (two tablets) of Predimenol or Placebo.

Conditions

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Headache

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Treatment Group

2 tablets of Predimenol (400 mg Predimenol)

Group Type EXPERIMENTAL

Predimenol tablet

Intervention Type DRUG

2 tablets of Predimenol (400 mg Predimenol) will be taken with 220 mL of water (one glass of water).

Treatment + Placebo Group

1 tablet of Predimenol (200 mg Predimenol) + 1 tablet of placebo

Group Type EXPERIMENTAL

Predimenol tablet + Placebo tablet of Predimenol

Intervention Type DRUG

1 tablet of Predimenol (200 mg Predimenol) + 1 tablet of placebo will be taken with 220 mL of water (one glass of water).

Control Group

2 tablets of placebo

Group Type PLACEBO_COMPARATOR

Placebo tablet of Predimenol

Intervention Type DRUG

2 tablets of placebo tablet of Predimenol will be taken with 220 mL of water (one glass of water).

Interventions

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Predimenol tablet

2 tablets of Predimenol (400 mg Predimenol) will be taken with 220 mL of water (one glass of water).

Intervention Type DRUG

Predimenol tablet + Placebo tablet of Predimenol

1 tablet of Predimenol (200 mg Predimenol) + 1 tablet of placebo will be taken with 220 mL of water (one glass of water).

Intervention Type DRUG

Placebo tablet of Predimenol

2 tablets of placebo tablet of Predimenol will be taken with 220 mL of water (one glass of water).

Intervention Type DRUG

Other Intervention Names

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HerbaPAIN

Eligibility Criteria

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Inclusion Criteria

1. Healthy men or women aged 18 to 60 years with acute moderate tomoderate-severe headache.
2. Signing the informed consent.

Exclusion Criteria

1. Body temperature of \>37.3˚C and/or refuse to follow health protocol for COVID-19.
2. Known hypersensitivity to herbal drugs.
3. Pregnant or lactating women.
4. Have received any analgesic or anti-inflammatory drugs within the past 12 hours.
5. Presence of vomiting or diarrhea within the past 24 hours or still ongoing at the start of study.
6. Severe illness, e.g. severe hypertension, or any known organic diseases that may cause headache.
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fakultas Kedokteran Universitas Indonesia

OTHER

Sponsor Role collaborator

Dexa Medica Group

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nalfriadi Nalfriadi, MD,SpPD,PhD

Role: PRINCIPAL_INVESTIGATOR

Department Pharmacology & Therapeutics Faculty of Medicine Universitas Indonesia

Locations

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Imeri Fkui

Jakarta Pusat, DKI Jakarta, Indonesia

Site Status

Klinik Satelit Makara UI Depok

Depok, West Java, Indonesia

Site Status

Countries

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Indonesia

Other Identifiers

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CRSU.P.Dexa/06/20/13.04

Identifier Type: -

Identifier Source: org_study_id

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