Intramuscular Lipid and Insulin Action:Ethnic Aspects

NCT ID: NCT00726908

Last Updated: 2012-06-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

69 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-04-30

Study Completion Date

2009-12-31

Brief Summary

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High levels of the hormone insulin are associated with risk for heart disease and diabetes, and may make it hard to lose weight. The types of food eaten may affect insulin levels. The purpose of this study is to determine if manipulation of dietary carbohydrate content improves insulin sensitivity (Si), augments weight loss, and promotes weight loss maintenance in healthy adults.

Detailed Description

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Conditions

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Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Interventions

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Low carbohydrate

43% CHO

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

Overweight, age 21-50 years,Women must be premenopausal, Normal glucose tolerance, weight stable for at least 6 months with a weight change no greater than 5 lbs.
Minimum Eligible Age

21 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

Sponsor Role collaborator

University of Alabama at Birmingham

OTHER

Sponsor Role lead

Responsible Party

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Barbara Gower

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Barbara A Gower, PhD

Role: PRINCIPAL_INVESTIGATOR

Univ. Alabama Birmingham

Locations

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University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

Countries

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United States

References

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Morrison SA, Goss AM, Azziz R, Raju DA, Gower BA. Peri-muscular adipose tissue may play a unique role in determining insulin sensitivity/resistance in women with polycystic ovary syndrome. Hum Reprod. 2017 Jan;32(1):185-192. doi: 10.1093/humrep/dew279. Epub 2016 Nov 8.

Reference Type DERIVED
PMID: 27827322 (View on PubMed)

Gower BA, Goss AM. A lower-carbohydrate, higher-fat diet reduces abdominal and intermuscular fat and increases insulin sensitivity in adults at risk of type 2 diabetes. J Nutr. 2015 Jan;145(1):177S-83S. doi: 10.3945/jn.114.195065. Epub 2014 Dec 3.

Reference Type DERIVED
PMID: 25527677 (View on PubMed)

Gower BA, Pollock NK, Casazza K, Clemens TL, Goree LL, Granger WM. Associations of total and undercarboxylated osteocalcin with peripheral and hepatic insulin sensitivity and beta-cell function in overweight adults. J Clin Endocrinol Metab. 2013 Jul;98(7):E1173-80. doi: 10.1210/jc.2013-1203. Epub 2013 Apr 24.

Reference Type DERIVED
PMID: 23616149 (View on PubMed)

Ellis AC, Casazza K, Chandler-Laney P, Gower BA. Higher postprandial serum ghrelin among African-American girls before puberty. J Pediatr Endocrinol Metab. 2012;25(7-8):691-6. doi: 10.1515/jpem-2012-0081.

Reference Type DERIVED
PMID: 23155695 (View on PubMed)

Ellis AC, Chandler-Laney P, Casazza K, Goree LL, Gower BA. Effects of habitual diet on ethnic differences in serum total ghrelin. Endocrine. 2012 Oct;42(2):359-65. doi: 10.1007/s12020-012-9667-2. Epub 2012 Apr 7.

Reference Type DERIVED
PMID: 22481313 (View on PubMed)

Goree LL, Chandler-Laney P, Ellis AC, Casazza K, Granger WM, Gower BA. Dietary macronutrient composition affects beta cell responsiveness but not insulin sensitivity. Am J Clin Nutr. 2011 Jul;94(1):120-7. doi: 10.3945/ajcn.110.002162. Epub 2011 May 18.

Reference Type DERIVED
PMID: 21593507 (View on PubMed)

Other Identifiers

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R01DK067538

Identifier Type: NIH

Identifier Source: secondary_id

View Link

F070322005

Identifier Type: -

Identifier Source: org_study_id

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