The Effect of Nocturnal Haemodialysis on Arterial Stiffness

NCT ID: NCT00641875

Last Updated: 2015-04-27

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 30 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2005-12-31
• Study Completion Date: 2008-02-29

Brief Summary

Arterial stiffness refers to the accumulation of extracellular deposits of matrix and calcium which reduce blood vessel compliance. Although there is growing evidence that increased arterial stiffness is associated with chronic kidney disease (CKD), its pathogenesis is unclear. Pulse wave velocity (PWV) and augmentation index (AIx) provide tools for estimating arterial stiffness, and therefore predicting cardiovascular morbidity and mortality. The aims of the study are: (1) compare the effects of nocturnal and conventional haemodialysis on arterial stiffness, and (2) examine the relationship between arterial stiffness and clinical and biochemical parameters.

Conditions

End Stage Renal Disease; Arterial Stiffness

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

Nocturnal Hemodialysis

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• adult dialysis patients
• able to perform home nocturnal haemodialysis

Exclusion Criteria

• age < 18 and > 80 years
• any patient who is anticipating a live renal transplantation in forthcoming 12 months

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Melbourne Health

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Michael Lian, FRACP, MBBS

Role: PRINCIPAL_INVESTIGATOR

Department of Nephrology, Melbourne Health

Other Identifiers

2004.050

Identifier Type: -

Identifier Source: org_study_id