Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
60 participants
INTERVENTIONAL
2005-08-31
2007-03-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
TRIPLE
Study Groups
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Midazolam
Pre-anesthetic medication with midazolam, 7.5 mg p.o., 60-90 min prior to estimated induction time
midazolam
midazolam, 7.5 mg p.o., 60-90 min prior to estimated induction time
Clonidine
pre-anesthetic medication with clonidine, 150 µg p.o., 60-90 min prior to estimated induction time
clonidine
pre-anesthetic medication with clonidine, 150 µg p.o., 60-90 min prior to estimated induction time
Placebo
Pre-anesthetic medication with an inert tablet, p.o., 60-90 min prior to estimated induction time
placebo
inert tablet p.o., 60-90 min prior to estimated induction time
Interventions
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midazolam
midazolam, 7.5 mg p.o., 60-90 min prior to estimated induction time
clonidine
pre-anesthetic medication with clonidine, 150 µg p.o., 60-90 min prior to estimated induction time
placebo
inert tablet p.o., 60-90 min prior to estimated induction time
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* ASA physical status I and II
* informed consent
* weight 50 - 100 kg
Exclusion Criteria
* pregnancy
* problems of consent due to mentally handicap or language.
18 Years
75 Years
ALL
No
Sponsors
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University Hospital Schleswig-Holstein
OTHER
Responsible Party
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Chair of the Department of Anaesthesiology and Intensive Care Medicine, University Schleswig-Holstein Campus Kiel
Principal Investigators
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Jens Scholz, M.D.
Role: STUDY_CHAIR
Chair of the Dept. of Anaesthesiology and Intensive Care Medicine, University of Schleswig-Holstein Campus Kiel
Locations
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Department of Anaesthesiology and Intensive Care Medicine, University of Schleswig-Holstein Campus Kiel
Kiel, , Germany
Countries
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References
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Matot I, Sichel JY, Yofe V, Gozal Y. The effect of clonidine premedication on hemodynamic responses to microlaryngoscopy and rigid bronchoscopy. Anesth Analg. 2000 Oct;91(4):828-33. doi: 10.1097/00000539-200010000-00011.
Carabine UA, Milligan KR, Moore JA. Adrenergic modulation of preoperative anxiety: a comparison of temazepam, clonidine, and timolol. Anesth Analg. 1991 Nov;73(5):633-7. doi: 10.1213/00000539-199111000-00021.
Ghignone M, Quintin L, Duke PC, Kehler CH, Calvillo O. Effects of clonidine on narcotic requirements and hemodynamic response during induction of fentanyl anesthesia and endotracheal intubation. Anesthesiology. 1986 Jan;64(1):36-42. doi: 10.1097/00000542-198601000-00007.
Grottke O, Muller J, Dietrich PJ, Krause TH, Wappler F. [Comparison of premedication with clonidine and midazolam combined with TCI for orthopaedic shoulder surgery]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2003 Dec;38(12):772-80. doi: 10.1055/s-2003-45396. German.
Liu J, Singh H, White PF. Electroencephalogram bispectral analysis predicts the depth of midazolam-induced sedation. Anesthesiology. 1996 Jan;84(1):64-9. doi: 10.1097/00000542-199601000-00007.
Brosius KK, Bannister CF. Oral midazolam premedication in preadolescents and adolescents. Anesth Analg. 2002 Jan;94(1):31-6, table of contents. doi: 10.1097/00000539-200201000-00006.
Lindahl SG. The use of midazolam in premedication. Acta Anaesthesiol Scand Suppl. 1990;92:79-83; discussion 107. doi: 10.1111/j.1399-6576.1990.tb03191.x.
Other Identifiers
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A 157/01
Identifier Type: -
Identifier Source: secondary_id
A 157/01
Identifier Type: -
Identifier Source: org_study_id