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Development of a Model to Evaluate Regenerative Endodontic Techniques Using Extract Human Teeth

NCT ID: NCT00595595

Last Updated: 2012-09-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1080 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-02-28

Study Completion Date

2012-09-30

Brief Summary

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Millions of teeth are saved each year by root canal therapy. Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue in order to revitalize teeth.

Detailed Description

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The long term goal of this research project is to develop a method to regenerate dental pulp-like tissue as an alternative method to conventional root canal treatment. The objective of this study is to identify the methods necessary to regenerate dental pulp-like tissue in human teeth. We will collect small (\~4X4mm) pieces of oral mucosa that are normally removed during surgical tooth extractions, isolate human postnatal progenitor/stem cells and, using an in vitro cell culture system, combined isolated cells with various scaffolds and test compounds to determine optimal conditions to differentiate pulp-like tissue (eg, odontoblasts, fibroblasts, endothelium, etc) grown in segments of human roots.

Conditions

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Dental Pulp Regeneration Dental Pulp Diseases

Keywords

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Dental Pulp Regenerative Medicine Odontoblasts Stem Cells Growth factor differentiation of stem/progenitor cells Odontoblast-specific cell phenotypes

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Pre-existing indication for surgical extraction of impacted teeth
* Age 16-65

Exclusion Criteria

* Ages less than 16 or over 65
* No pre-existing indication for surgical extraction of impacted teeth
Minimum Eligible Age

16 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The University of Texas Health Science Center at San Antonio

OTHER

Sponsor Role lead

Responsible Party

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Kenneth Hargreaves

Chair, Dept. of Endodontics

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Kenneth M Hargreaves, DDS, PhD

Role: PRINCIPAL_INVESTIGATOR

The University of Texas Health Science Center at San Antonio

Locations

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The University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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HSC20070149H

Identifier Type: -

Identifier Source: org_study_id