Bands in Peripheral Blood After Coronary Artery Bypass Grafting With and Without Cardiopulmonary Bypass
NCT ID: NCT00563030
Last Updated: 2009-11-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
44 participants
OBSERVATIONAL
2007-12-31
2009-05-31
Brief Summary
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The aim of the study is to compare signs of SIRS (heart rate, tachypnea or hypocarbia, leukocytosis, hyperpyrexia or hypothermia) and the granulocytes subsets in peripheral blood from patients who underwent CABG surgery with or without use of CPB.
The researchers expect significant differences in SIRS criteria between both groups. If the differences will occur significant, the parameter may be used as candidate variable for a complications prediction model after CABG surgery.
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Detailed Description
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After arrival into the operating theatre 4.5 ml blood will be obtained into EDTA vials from a peripheral venous canula, placed previously for routine anesthesiologic management.
Additional blood samples will be obtained 3, 6, 12, 24 and 48 hours after the operation. Each vial will be immediately labeled with an identification number and submitted into the laboratory, where smear with May-Grunwald-Giemsa staining will be prepared. The smear will be panoptical examined for 400 consecutive leucocytes and assigned to one of the following lines: neutrophils, eosinophils, basophils, monocytes and lymphocytes. Neutrophils will be further divided into: segments, bands, metamyelocytes, myelocytes, promyelocytes, myeloblasts.
The laboratory staff will be blinded for type of operation. Differences in subsets of granulocytes between groups and timepoints wil be analysed as means by appropriate parametric or nonparametric statistical tests.
The SIRS criteria will be refered to:
1. Intraoperative variables: number of distal anastomoses, time of aorta/artery clamping, time of intraoperative hypotension, suction pump use, serum lactates;
2. Postoperative variables: serum CRP, blood products transfusion, chest tube drainage.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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1
Patients undergoing CABG with CPB
No interventions assigned to this group
2
Patients undergoing off-pump CABG
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Signed informed consent
Exclusion Criteria
* Signs of infection and/or inflammation (at least 2/4 SIRS criteria)
* Emergency operation
* Organ failure/dysfunction
18 Years
ALL
No
Sponsors
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Medical University of Gdansk
OTHER
Responsible Party
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Medical University of Gdańsk
Principal Investigators
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Maciej M Kowalik, MD, PhD
Role: STUDY_DIRECTOR
Medical University of Gdańsk, Dept. of Cardiac Anesthesiology
Locations
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Medical University of Gdańsk, Dept. of Cardiac Anesthesiology
Gdansk, , Poland
Countries
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References
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Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992 Jun;101(6):1644-55. doi: 10.1378/chest.101.6.1644.
Santa Ursula Tolosa JA, Criado A, Garcia del Valle S, Pensado A, Barbolla L, Carmona Aurioles JA. [Changes in total and differential leukocyte counts during heart surgery with extracorporeal circulation]. Rev Esp Anestesiol Reanim. 1991 Mar-Apr;38(2):94-7. Spanish.
Orr Y, Taylor JM, Bannon PG, Geczy C, Kritharides L. Circulating CD10-/CD16low neutrophils provide a quantitative index of active bone marrow neutrophil release. Br J Haematol. 2005 Nov;131(4):508-19. doi: 10.1111/j.1365-2141.2005.05794.x.
Orr Y, Wilson DP, Taylor JM, Bannon PG, Geczy C, Davenport MP, Kritharides L. A kinetic model of bone marrow neutrophil production that characterizes late phenotypic maturation. Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1707-16. doi: 10.1152/ajpregu.00627.2006. Epub 2006 Dec 21.
Related Links
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home page of Dept. of Cardiac Anesthesiology, Medical University of Gdańsk
Other Identifiers
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AMG-NKEBN/272/2007
Identifier Type: -
Identifier Source: org_study_id
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