Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty
NCT ID: NCT00562627
Last Updated: 2011-08-08
Study Results
Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.
View full resultsBasic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
PHASE4
102 participants
INTERVENTIONAL
2007-11-30
2009-07-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
The aim of this study is to:
1. Compare analgetic efficacy of to types of local infiltration analgesia in total knee arthroplasty.
2. Compare analgetic efficacy of local infiltration analgesia with continuous epidural analgesia.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Postoperative Analgesia After Total Knee Arthroplasty
NCT00421967
Implementation of a Pain Management Protocol for Total Knee Arthroplasty
NCT02474654
Comparison of Patient-controlled Analgesia Regimenfor Postoperative Pain in Patients Undergoing Total Knee Arthroplasty
NCT05861791
Use of Local Infiltration Analgesia Following Total Hip Arthroplasty
NCT01344395
The Efficacy of Adductor-Canal-Blockade on Pain and Morphine Consumption After Total Knee Arthroplasty
NCT01261897
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Continuous epidural analgesia is often used for controlling pain after TKA. Recent studies describe a new method for pain control after total knee arthroplasty which consists of local infiltration with local anesthetics and adrenaline. This infiltrations can be combined with ketorolac and/or morphine. The aim of this study is to:
1. Compare analgetic efficacy of to types of local infiltration analgesia in total knee arthroplasty.
2. Compare analgetic efficacy of local infiltration analgesia with continuous epidural analgesia.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
LIA IV
Local infiltration analgesia with ropivacaine and adrenaline and intravenous ketorolac and morphine
ropivacaine
intraoperative and 1. postoperative day
adrenaline
intraoperative LIA (IV and IA) and continuous EDA
ketorolac
intraoperative and 1. postoperative day
morphine
intraoperative
LIA IA
Local infiltration analgesia with ropivacaine, adrenaline and ketorolac and morphine
ropivacaine
intraoperative and 1. postoperative day
adrenaline
intraoperative LIA (IV and IA) and continuous EDA
ketorolac
intraoperative and 1. postoperative day
morphine
intraoperative
EDA
standard continuous epidural analgesia
adrenaline
intraoperative LIA (IV and IA) and continuous EDA
fentanyl
continuous postoperatively
bupivacaine
continuous postoperatively
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
ropivacaine
intraoperative and 1. postoperative day
adrenaline
intraoperative LIA (IV and IA) and continuous EDA
ketorolac
intraoperative and 1. postoperative day
morphine
intraoperative
fentanyl
continuous postoperatively
bupivacaine
continuous postoperatively
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* scheduled for elective total knee arthroplasty
* ASA I-III
* signed written informed consent
Exclusion Criteria
* ASA \> III
* moderate or severe cardiac disease, bronchial asthma
* allergy against ropivacaine, ketorolac or morphine
* analgetic abuse
* pregnancy or nursing women
* severe psychiatric disease
* moderate to severe dementia
18 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Asker & Baerum Hospital
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Asker and Baerum Hospital
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Ulrich J Spreng, MD
Role: PRINCIPAL_INVESTIGATOR
Asker and Baerum Hospital
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Asker and Baerum Hospital
Rud, , Norway
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Spreng UJ, Dahl V, Hjall A, Fagerland MW, Raeder J. High-volume local infiltration analgesia combined with intravenous or local ketorolac+morphine compared with epidural analgesia after total knee arthroplasty. Br J Anaesth. 2010 Nov;105(5):675-82. doi: 10.1093/bja/aeq232. Epub 2010 Aug 24.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
EudraCT 2007-003030-41
Identifier Type: -
Identifier Source: secondary_id
REK 1.2007.1603
Identifier Type: -
Identifier Source: secondary_id
2007-003030-41
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.