RCT on Ketorolac and Tramadol in Bone Fractures Pain of Child

NCT ID: NCT00560443

Last Updated: 2017-08-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

133 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-02-29

Study Completion Date

2012-04-30

Brief Summary

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Randomized double blind Trial with the aim to estimate effectiveness of two therapeutic regimes per os on pain due to not compound bone fractures in child 4-17 years old:

* ketorolac 0,5 mg/kg (1 drop every 2 Kg)
* tramadol 2,5 mg/Kh (1 drop every 2 Kg)

Intensity of pain will be estimated with linear 1 to 10 or analogic McGrath type scale every 20 min.

The main objectives are the evaluation of pain decreasing in every group, the time of decreasing, the intensity of pain during procedures (ex. Xray) and the occurrence of side effects Secondary outcomes are comparison between the two groups on effectiveness on pain and on side effects

Detailed Description

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Conditions

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Fracture Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

children 4-17 y. old with not compound bone fracture treated with ketorolac

Group Type ACTIVE_COMPARATOR

ketorolac

Intervention Type DRUG

0,5 mg/kg per os one time

2

children 4-17 y. old with not compound bone fracture treated with tramadol

Group Type EXPERIMENTAL

tramadol

Intervention Type DRUG

2,5 mg/ kg per os in one dose

Interventions

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ketorolac

0,5 mg/kg per os one time

Intervention Type DRUG

tramadol

2,5 mg/ kg per os in one dose

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Children 4-17 years old with not compound bone fracture presenting in emergency room

Exclusion Criteria

* Compound fracture
* Occurring pain still treated
* Contraindicated ketorolac or tramadol use
* Informed consensus not obtained
Minimum Eligible Age

4 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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IRCCS Burlo Garofolo

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Edoardo Guglia, md

Role: PRINCIPAL_INVESTIGATOR

IRCCS Burlo Garofolo

Locations

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IRCCS Burlo Garofolo

Trieste, , Italy

Site Status

Countries

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Italy

References

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Neri E, Maestro A, Minen F, Montico M, Ronfani L, Zanon D, Favret A, Messi G, Barbi E. Sublingual ketorolac versus sublingual tramadol for moderate to severe post-traumatic bone pain in children: a double-blind, randomised, controlled trial. Arch Dis Child. 2013 Sep;98(9):721-4. doi: 10.1136/archdischild-2012-303527. Epub 2013 May 23.

Reference Type DERIVED
PMID: 23702435 (View on PubMed)

Other Identifiers

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RC 30/07

Identifier Type: -

Identifier Source: org_study_id

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