Hormone Dynamics and Bone Mineral Density in Anorexia Nervosa v. Hypothalamic Amenorrhea

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

61 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-03-31

Study Completion Date

2009-03-31

Brief Summary

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The purpose of this study is to determine whether the hormone dynamics in women with anorexia nervosa and hypothalamic amenorrhea is related to bone loss in those populations.

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Detailed Description

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Conditions

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Anorexia Nervosa Hypothalamic Amenorrhea Obesity

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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1

lean healthy women, age 18-45

No interventions assigned to this group

2

overweight healthy women, age 18-45

No interventions assigned to this group

3

women with hypothalamic amenorrhea (have not had a period in three months), age 18-45

No interventions assigned to this group

4

women with anorexia nervosa, age 18-45

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Amenorrhea for at least three months (unless participating as healthy control)
* Normal TSH or free thyroxine (free T4).

Exclusion Criteria

* A condition known to affect bone metabolism, including Cushing's syndrome or renal failure, with the exception of bone fracture.
* Any medication known to affect bone metabolism within 3 months of the study, including estrogen and progestins. Patients receiving depot medroxyprogesterone (Depo-Provera) will be excluded from participating for 6 months after their last injection.
* Pregnant and/or breastfeeding.
* Diabetes mellitus.
* Active substance abuse, including alcohol.

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes