Long Term Follow-up of Bone Mineral Density in Hormone Treated Turner Syndrome

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

54 participants

Study Classification

OBSERVATIONAL

Study Start Date

1994-11-30

Study Completion Date

2010-06-30

Brief Summary

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Turner Syndrome (TS) is associated with osteopenia and osteoporosis. Reduced bone mineral density (BMD) and increased risk of fractures are present in many younger and middle-aged women with TS. The objective is therefore to describe longitudinal changes in BMD in TS.

The study is an observational follow-up study. Examinations at baseline, after 5 and 10 years.

Bone mineral density is measured by dual energy x-ray absorptiometry (DEXA) and bone turnover by bone markers.

Main Outcome Measures: Bone mineral density (BMD; grams/ square centimetre) were measured at lumbar spine, hip and the non-dominant forearm.

Detailed Description

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Conditions

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Turner Syndrome

Keywords

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Turner Syndrome bone mineral density estrogen replacement therapy dual energy x-ray absorptiometry

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Women with Turner syndrome

No interventions assigned to this group

2

Healthy control women

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Turner syndrome verified by karyotyping

Exclusion Criteria

* untreated hypothyroidism or hyperthyroidism
* present or past malignant diseases
* clinical liver disease
* treatment with drugs known to interfere with bone metabolism (e.g. glucocorticoids)

Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Responsible Party

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University of Aarhus

Other Identifiers

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1994/2424

Identifier Type: -

Identifier Source: org_study_id