Bone Mass Changes in Anorexia Nervosa Patient Followed During 4 Years

NCT ID: NCT02891356

Last Updated: 2025-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

180 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-07-31

Study Completion Date

2022-12-31

Brief Summary

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The mechanism of bone loss in anorexia nervosa is complex. Marrow adipose tissue seems to play a role in the regulation of bone metabolism. Adipocytes secrete cytokines and adipokines that either stimulate or inhibit adjacent osteoblasts. This study consist to explore the relationship in anorexia nervosa patients with change in bone mineral density and adipokines like leptin, adiponectin and Préf-1 Bone mineral densities will be measure in 180 anorexia nervosa patients at inclusion and every two years during 6 years.It is assessed blood and urinary calcium and phosphate levels, bone remodelling markers and adipokines (leptin, adiponectin and Préf-1)

Detailed Description

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Conditions

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Anorexia Nervosa Osteoporosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Anorexia patient

Dual Energy X-ray Absorptiometry (DEXA)

DEXA

Intervention Type DEVICE

The Dual Energy X-ray Absorptiometry (DEXA) is a third generation multi-captor DEXA device that allow short duration measurements. It measures Bone Mineral Density (BMD) at the spine and the femoral neck

Interventions

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DEXA

The Dual Energy X-ray Absorptiometry (DEXA) is a third generation multi-captor DEXA device that allow short duration measurements. It measures Bone Mineral Density (BMD) at the spine and the femoral neck

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* anorexia patient defined by DSM IV diagnostic criteria

Exclusion Criteria

* patient with other psychiatric disease
* patient with other a metabolic bone disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Lille

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Isabelle LEGROUX, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Lille

Locations

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Hôpital Roger Salengro, CHRU de Lille

Lille, , France

Site Status

Countries

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France

Other Identifiers

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2012-A01009-34

Identifier Type: OTHER

Identifier Source: secondary_id

2011_38

Identifier Type: -

Identifier Source: org_study_id

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