Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
45 participants
INTERVENTIONAL
2022-12-01
2024-07-01
Brief Summary
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In this project, a multidisciplinary team will tailor a bone-specific exercise and nutrition program to increase BMD in sport active and non-active wheelchair users with initial low BMD.
Detailed Description
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1. Bone health, measured as changes in BMD and blood bone markers.
2. Physical health, including body composition and muscular fitness.
3. Mental health, with focus on well-being, QOL and user experience.
The secondary aim is to use this knowledge to develop recommendations and implementation plans for exercise and nutrition to promote bone health of wheelchair users.
Using a randomized controlled design, participants will undergo an exercise intervention in which the participants also will receive nutritional optimization for bone remodelling. Main outcomes are change in BMD, blood bone markers, physical health and mental health parameters. Based on the outcomes of the RCT, the researchers will develop evidence-based practical health promoting recommendations and an implementation plan for health practitioners working with wheelchair users in the municipalities.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Training group
Group A: strength training 3x/week + nutrition optimalisation
Bone-specific strength training
Muscular strength and rate of force development (RFD) will be assessed in the key exercises of the intervention protocol
Nutrition optimalisation
Dietary supplement of protein, vitamin D and Calcium 3x/w Dietary counselling based on individual dietary records
Nutrition group
Group B: nutrition optimalisation
Nutrition optimalisation
Dietary supplement of protein, vitamin D and Calcium 3x/w Dietary counselling based on individual dietary records
Interventions
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Bone-specific strength training
Muscular strength and rate of force development (RFD) will be assessed in the key exercises of the intervention protocol
Nutrition optimalisation
Dietary supplement of protein, vitamin D and Calcium 3x/w Dietary counselling based on individual dietary records
Eligibility Criteria
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Inclusion Criteria
* primary aid for mobility being a manual wheelchair, i.e. ≥50% of the time
* 18-60 Y
* congenital (i.e., CP, spina bifida, dysmelia, hip dysplasia) and acquired disabilities (i.e., SCI, amputation)
* non-progressive impairment, and in the case of SCI; ≥ 2 years since time of injury
* ability to perform key exercises (e.g., overhead press)
Exclusion Criteria
* change in health and/or medication within the last 3 months
* fractures affecting measured sites or contraindicating strength testing/training
* menopausal, pregnancy or planned pregnancy during the study period
* language or cognitive barriers affecting the ability to understand all aspects of the study
* • patients with progressive neurological disease, serious or uncontrollable epilepsy, endocrine diseases (including diabetes mellitus type 1 or 2, thyroid disorders, calcium homeostasis disorders and metabolic bone disease, pituitary gland disorder, sex hormone disorders), cancer, serious mental disorder, or comorbid medical conditions affecting either a) nutritional function: i.e., malabsorption problems due to previous surgery in the gastrointestinal tract, inflammatory bowel disease, coeliac disease, eating disorders, chronic pancreatitis, liver or kidney disease (those that cannot convert vitamin D to its active form in the body), other conditions affecting vitamin D or calcium absorption; b) musculoskeletal system: i.e., congenital systemic skeletal dysplasia affecting bone density, inflammatory arthritis conditions (such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and lupus), ongoing tendinitis or muscle injuries not compatible with the exercise intervention; c) cardiovascular system: i.e. congenital heart failure, congenital connective tissue disorders affecting the aorta and/or arteries, other cardiovascular conditions not compatible with the exercise intervention;
* the use of certain medications: bisphosphonates, PTH (teriparatide), Denosumab, Raloksiphen, Prednisolone/steroids/androgenic steroids, high dose oestrogen (including medroxyprogesterone acetate contraceptives) immunosuppressive medications/ chemotherapies, vitamin K, anti-epileptic medication (Lamotrigine, Phenytoin, Phenobarbital, Carbamazepine, Primidone), proton pump inhibitors (PPIs), selective serotonin receptor inhibitors (SSRIs), thiazolidinediones (TZDs), anticonvulsants, hormone deprivation therapy, calcineurin inhibitors, and isotretinoin.
* other therapies that aim to increase bone mineral density, e.g., vibration therapy, functional electrical stimulation (FES)
* alternative medicine that interfere with vitamin D or calcium metabolism or affect bone mineral density
* known other contraindication of resistance exercise.
18 Years
60 Years
ALL
Yes
Sponsors
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Sunnaas Rehabilitation Hospital
OTHER
Norwegian University of Science and Technology
OTHER
HAN University of Applied Sciences
OTHER
Norwegian School of Sport Sciences
OTHER
Responsible Party
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Kristin L. Jonvik
Principal investigator
Locations
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Norwegian School of Sport Sciences
Oslo, , Norway
Countries
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Other Identifiers
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NorwegianSSS BoneWheel
Identifier Type: -
Identifier Source: org_study_id