Cutivate Lotion HPA Axis Pediatric Study

NCT ID: NCT00546000

Last Updated: 2014-07-24

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

56 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-07-31

Study Completion Date

2008-12-31

Brief Summary

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A multi-center, open-label, Phase IV, unblinded study using Cutivate (fluticasone propionate, 0.05%)lotion and it's possible effects on the HPA axis of infants diagnosed with atopic dermatitis.

Detailed Description

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Conditions

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Atopic Dermatitis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Receive between 22 and 29 days of Cutivate lotion treatment

Group Type EXPERIMENTAL

Fluticasone propionate 0.05% lotion

Intervention Type DRUG

Daily applications

Interventions

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Fluticasone propionate 0.05% lotion

Daily applications

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Subjects are 3-12 months of age
* Subjects diagnosed with Atopic Dermatitis (AD) and have ≥35% of Body Surface Area
* Subjects meet protocol specific AD signs and symptom severity score

Exclusion Criteria

* Subjects with conditions effecting the HPA Axis
* Subjects with clinically significant systemic disease
* Subjects who require treatment with systemic or topical retinoids during the study
* Subjects who have been treated with various chronic therapies identified in the protocol
* Subjects who have received other investigational drug treatment within 30 days prior to study entry
Minimum Eligible Age

3 Months

Maximum Eligible Age

12 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fougera Pharmaceuticals Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Alan Fleischer Jr., M.D.

Role: PRINCIPAL_INVESTIGATOR

Wake Forest University Health Sciences

Lawrence F. Eichenfield, MD

Role: PRINCIPAL_INVESTIGATOR

Rady Children's Hospital, San Diego

Elizabeth Connelly, MD

Role: PRINCIPAL_INVESTIGATOR

University of Miami

Craig L. Leonardi, MD

Role: PRINCIPAL_INVESTIGATOR

Central Dermatology

Lawrence Parish, MD

Role: PRINCIPAL_INVESTIGATOR

Paddington Testing Company, Inc

Adelaide A Hebert, MD

Role: PRINCIPAL_INVESTIGATOR

The University of Texas Health Science Center, Houston

Sharon Raimer, MD

Role: PRINCIPAL_INVESTIGATOR

University of Texas Medical Branch, Galveston

Kenneth E. Bloom, MD

Role: PRINCIPAL_INVESTIGATOR

Dermatology Center for Children and Young Adults

David L Kaplan, MD

Role: PRINCIPAL_INVESTIGATOR

Adult & Pediatric Dermatology

Stephen W. Shewmake, M.D.

Role: PRINCIPAL_INVESTIGATOR

Centre for Health Care Medical Associates

Locations

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Centre for Health Care Medical Associates

Poway, California, United States

Site Status

Rady Children's Hospital, San Diego

San Diego, California, United States

Site Status

University of Miami, Dept. of Dermatology

Miami, Florida, United States

Site Status

Adult & Pediatric Dermatology

Overland Park, Kansas, United States

Site Status

Dermatology Center for Children and Young Adults

Eagan, Minnesota, United States

Site Status

Central Dermatology

St Louis, Missouri, United States

Site Status

Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States

Site Status

Paddington Testing Company, Inc

Philadelphia, Pennsylvania, United States

Site Status

University of Texas Medical Branch

Galveston, Texas, United States

Site Status

University of Texas Health Science Center

Houston, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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ALT 0434-01-01

Identifier Type: -

Identifier Source: org_study_id

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