Continued Safety Evaluation of FB-401 in Children, Adolescents and Adults (2 Years and Older) With Mild to Moderate Atopic Dermatitis Previously Enrolled in the FB401-01 Study

NCT ID: NCT04936113

Last Updated: 2021-10-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Clinical Phase

PHASE2

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-06-02

Study Completion Date

2021-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to evaluate the continued safety and tolerability of FB-401 in subjects 2 years of age or older with mild to moderate atopic dermatitis. FB-401 will be applied topically for up to 48 additional weeks and subjects will be evaluated for safety.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Atopic Dermatitis

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Atopic dermatitis microbiome probiotic commensal Gram-negative bacteria transdermal water loss allergic diseases dermatitis eczema skin diseases skin diseases, eczematous immune system diseases

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

FB-401

FB-401 applied topically

Group Type EXPERIMENTAL

FB-401

Intervention Type BIOLOGICAL

Topical

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

FB-401

Topical

Intervention Type BIOLOGICAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Participated in Protocol FB401-01, completed through Week 20 visit and able to directly enroll into this (FB401-02) study
* Refrain from use of all other atopic dermatitis treatments, unless given permission by medical monitor

Exclusion Criteria

* Subject experienced a serious adverse event or severe adverse event attributable to study drug in Protocol FB401-01
* Severe concomitant illness that, in the Investigator's opinion, would adversely affect subject participation in the study, whether medical or psychological
* Pregnant (or planning to become pregnant during the period of the study) or lactating females
Minimum Eligible Age

2 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Forte Biosciences, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Center for Dermatology Clinical Research, Inc.

Fremont, California, United States

Site Status

Multi-Specialty Research Associates, Inc.

Lake City, Florida, United States

Site Status

MedaPhase, Inc

Newnan, Georgia, United States

Site Status

DS Research

Clarksville, Indiana, United States

Site Status

DS Research

Louisville, Kentucky, United States

Site Status

Cyn3rgy Research

New Brighton, Minnesota, United States

Site Status

Cyn3rgy Research

Gresham, Oregon, United States

Site Status

Bellaire Dermatology Associates

Bellaire, Texas, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

References

Explore related publications, articles, or registry entries linked to this study.

Myles IA, Earland NJ, Anderson ED, Moore IN, Kieh MD, Williams KW, Saleem A, Fontecilla NM, Welch PA, Darnell DA, Barnhart LA, Sun AA, Uzel G, Datta SK. First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis. JCI Insight. 2018 May 3;3(9):e120608. doi: 10.1172/jci.insight.120608.

Reference Type BACKGROUND
PMID: 29720571 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

FB401-02

Identifier Type: -

Identifier Source: org_study_id