Hyperbilirubinemia in Acute Appendicitis as a Predictor of Perforation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

132 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-10-31

Study Completion Date

2008-09-30

Brief Summary

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It has recently been published that hyperbilirubinemia is a reliable marker for the preoperative diagnosis of perforated acute appendicitis.

The investigators believe, based on their own previous publications, that C-reactive protein (CRP) with or without a white blood cell count and some other clinical parameters, are more specific markers for the preoperative diagnosis of perforated acute appendicitis.

The purpose of this study is to prospectively compare the specificity and sensitivity of hyperbilirubinemia CRP, white blood cell count and other clinical parameters for the preoperative diagnosis of acute appendicitis.

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Detailed Description

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* Previously validated appendicitis score
* Time from onset of symptoms to diagnosis and to surgery
* Laboratory values: WBC, CRP, liver function test
* SIRS values
* Preoperative and postoperative diagnosis
* Length of hospital stay
* Postoperative complications
* Biopsy results

Conditions

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Perforated Appendicitis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Simple appendicitis

Laboratory Test

Intervention Type OTHER

CRP, white blood cell count, hepatic function tests

2

Perforated appendicitis

Laboratory Test

Intervention Type OTHER

CRP, white blood cell count, hepatic function tests

Interventions

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Laboratory Test

CRP, white blood cell count, hepatic function tests

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients scheduled for appendectomies for acute appendicitis at the emergency unit of our institution
* Patients older than 15 years of age to 100 years of age

Exclusion Criteria

* Appendectomy performed incidentally or for other indications
* Patients younger than 15 years of age
* Alcoholism
* A history of viral hepatitis
* Gilbert's disease
* Dubin Johnson syndrome
* BRIC (benign recurrent intra-hepatic cholestasis) and other documented biliary
* Hemolytic or liver diseases associated with hyperbilirubinaemia

Minimum Eligible Age

15 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No