Cancer Genetics CD-ROM for Hispanics

NCT ID: NCT00525980

Last Updated: 2013-04-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

37 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-02-28

Study Completion Date

2013-03-31

Brief Summary

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This project will build upon prior, successful research on the effectiveness of an interactive computer disk with readable only memory (CD-ROM) for educating women about breast cancer and genetic risk. Prior studies found that an interactive CD-ROM for educating women about breast cancer risk and genetic testing was effective. The program was well received by lay persons and professionals. In a randomized controlled trial conducted at multiple sites, the CD-ROM intervention was highly effective in increasing knowledge, especially among women at low risk of carrying a breast cancer susceptibility gene 1/2 (BRCA1/2) mutation.

Researchers now propose to expand the use of the interactive CD-ROM in two innovative ways. The overall goal of this proposal is to evaluate the program as a first-line educational approach for Hispanic women on the Texas-Mexico border, where educational resources about cancer genetics are limited. First, researchers will modify and adapt the program for a primarily Hispanic population, in order to make it culturally and linguistically appropriate to the needs of that audience.

Second, researchers will evaluate the program as a first-line educational method among women with a personal or family history of breast cancer. Researchers will compare the effectiveness of the CD-ROM when implemented with and without the guidance of a trained promotora, and in comparison with standard educational materials (usual care condition).

The specific aims of this study include:

Aim 1: To modify the interactive CD-ROM to: a) make it culturally and linguistically appropriate for Hispanic women residing along the Texas-Mexico border; b) reflect current knowledge about breast cancer genetics; c) add a module to help women prepare to discuss their family history and cancer risk with a health care provider (n=50 participants).

Aim 2: To conduct a randomized, controlled evaluation that compares the efficacy of the modified CD-ROM when used alone vs. when used with a promotora-assisted approach vs. standard written materials (n=414 participants).

Detailed Description

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This study will test ways to help improve Hispanic women's knowledge and understanding about breast cancer risk and genetic testing for inherited cancer risk. These methods include providing printed educational materials, using an educational computer program, and using the computer program with the assistance of a lay health worker (a promotora).

If you agree to take part in this study, you will complete a questionnaire that will ask about your personal health as well as your knowledge and attitudes toward cancer and genetic testing. After the questionnaire is completed, you will be randomly assigned (as in the roll of dice) to 1 of 3 study groups. One group will be asked to read educational materials. Another group will use an educational computer program to learn about breast cancer risk and genetic testing without guidance. Another group will use the computer program with the guidance of a promotora.

Each of the 3 study groups should take between 30 and 60 minutes to complete.

Immediately after participating in your assigned group, you will be asked to complete another questionnaire that will ask about your knowledge and attitudes toward cancer and genetic testing. You will also be contacted later by telephone to complete similar questionnaires at about 1 month and 6 months after your study visit. Some women will be asked to complete an additional questionnaire by telephone 1 week after reading the educational materials or the computer program, and researchers will ask for permission to audiotape this interview. It will take about 20 minutes to complete each of the questionnaires used in this study.

This is an investigational study. Up to 414 women will take part in this study.

Conditions

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Breast Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group 1: Written Materials

One group asked to read educational materials.

Group Type EXPERIMENTAL

Focus Group

Intervention Type BEHAVIORAL

Focus group discussion lasting about 60 to 90 minutes.

Written Materials

Intervention Type OTHER

Printed materials will be given. The CD-ROM will be offered at the end of the study.

Questionnaires

Intervention Type BEHAVIORAL

Occasional questionnaire, written or verbal phone survey, about knowledge and attitudes toward cancer and genetic testing.

Group 2: Computer Program Only

Group 2 use an educational computer program to learn about breast cancer risk and genetic testing without guidance.

Group Type EXPERIMENTAL

Computer Program

Intervention Type BEHAVIORAL

Participants will be given a program to learn about breast cancer risk and genetic testing.

Arm 3 Only = Participants will use the program with the assistance of a promotora (female "promoter," community health worker, sometimes known as a lay health advisor).

Focus Group

Intervention Type BEHAVIORAL

Focus group discussion lasting about 60 to 90 minutes.

Questionnaires

Intervention Type BEHAVIORAL

Occasional questionnaire, written or verbal phone survey, about knowledge and attitudes toward cancer and genetic testing.

Group 3: Computer Program + Promotora

Group 3 use the computer program with the guidance of a promotora.

Group Type EXPERIMENTAL

Computer Program

Intervention Type BEHAVIORAL

Participants will be given a program to learn about breast cancer risk and genetic testing.

Arm 3 Only = Participants will use the program with the assistance of a promotora (female "promoter," community health worker, sometimes known as a lay health advisor).

Focus Group

Intervention Type BEHAVIORAL

Focus group discussion lasting about 60 to 90 minutes.

Questionnaires

Intervention Type BEHAVIORAL

Occasional questionnaire, written or verbal phone survey, about knowledge and attitudes toward cancer and genetic testing.

Interventions

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Computer Program

Participants will be given a program to learn about breast cancer risk and genetic testing.

Arm 3 Only = Participants will use the program with the assistance of a promotora (female "promoter," community health worker, sometimes known as a lay health advisor).

Intervention Type BEHAVIORAL

Focus Group

Focus group discussion lasting about 60 to 90 minutes.

Intervention Type BEHAVIORAL

Written Materials

Printed materials will be given. The CD-ROM will be offered at the end of the study.

Intervention Type OTHER

Questionnaires

Occasional questionnaire, written or verbal phone survey, about knowledge and attitudes toward cancer and genetic testing.

Intervention Type BEHAVIORAL

Other Intervention Names

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Survey

Eligibility Criteria

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Inclusion Criteria

* Residing in the El Paso metropolitan area and self-identifying as Hispanic
* Being 18 years of age or older
* Women who have a personal history of breast cancer or have a first-degree relative with breast cancer OR lay health workers (male or female)
* Able to provide informed consent

Exclusion Criteria

* Having a primary language other than English or Spanish
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Human Genome Research Institute (NHGRI)

NIH

Sponsor Role collaborator

National Institutes of Health (NIH)

NIH

Sponsor Role collaborator

M.D. Anderson Cancer Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Susan Peterson, PhD

Role: PRINCIPAL_INVESTIGATOR

M.D. Anderson Cancer Center

Locations

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The Cancer and Chronic Disease Consortium (CCDC) of El Paso

El Paso, Texas, United States

Site Status

UT MD Anderson Cancer Center

Houston, Texas, United States

Site Status

Countries

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United States

Related Links

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http://www.mdanderson.org

UT MD Anderson Cancer Center website

Other Identifiers

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2006-0339

Identifier Type: -

Identifier Source: org_study_id

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