Study of Genes and Environment in Patients With Breast Cancer in the East Anglia Region of the United Kingdom
NCT ID: NCT00757211
Last Updated: 2013-08-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
6000 participants
OBSERVATIONAL
2008-02-29
Brief Summary
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PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in patients with breast cancer.
Detailed Description
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* To obtain epidemiological information and biological material on a population-based series of breast cancer cases.
* To establish whether polymorphisms in putative cancer predisposition genes are associated with an increased risk of breast cancer by comparing the frequency of alterations in breast cancer patients with the corresponding frequency in controls.
* To define the proportion of breast cancer incidence attributable to mutations in such genes.
* To examine the interactions between genetic and nongenetic risk factors.
* To evaluate the relationship between pathological and clinical characteristics of breast cancers and germline genotype.
OUTLINE: This is a multicenter study.
Patients complete an epidemiological questionnaire that covers standard known breast cancer risk factors including reproductive history, oral contraceptive use, hormone replacement therapy use, family history, and alcohol consumption. The questionnaire will also request identifying information on the patient's first-degree relatives.
Blood samples are collected from patients. DNA is extracted from these blood samples, from samples collected from cancer-free control participants in MREC-SEARCH-CONTROL, and from additional controls through the European Prospective Investigation of Cancer (EPIC) study (a population-based study of diet and health based in Norfolk, East Anglia). DNA samples are analyzed for polymorphisms of low penetrance cancer susceptibility genes.
In addition to the breast cancer patients recruited for this study, patients with malignant melanoma and lymphoma, colorectal, ovarian, prostate, colorectal, bladder, kidney, pancreatic, and esophageal cancer, and brain tumors are recruited for the following related clinical trials: MREC-SEARCH-COLORECTAL, MREC-SEARCH-OVARIAN, MREC-SEARCH-PROSTATE, MREC-SEARCH-ENDOMETRIAL, and MREC-SEARCH-CANCER.
Conditions
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Keywords
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Interventions
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polymorphism analysis
laboratory biomarker analysis
questionnaire administration
Eligibility Criteria
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Inclusion Criteria
* Diagnosis of breast cancer within the past 5 years
* Identified through the East Anglian Cancer Registry in the East Anglia region of the United Kingdom
* Hormone receptor status not specified
PATIENT CHARACTERISTICS:
* Menopausal status not specified
* Identified by the patient's general practitioner as fit to contact for this study
* No serious mental illness or retardation
PRIOR CONCURRENT THERAPY:
* Not specified
18 Years
70 Years
ALL
No
Sponsors
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Cancer Research UK
OTHER
Principal Investigators
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Paul Pharoah, MD
Role: STUDY_CHAIR
Cancer Research UK
Locations
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University of Cambridge Cancer Research UK
Cambridge, England, United Kingdom
Countries
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Facility Contacts
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Contact Person
Role: primary
Other Identifiers
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MREC-SEARCH-BREAST
Identifier Type: -
Identifier Source: secondary_id
MREC-07/MRE05/17
Identifier Type: -
Identifier Source: secondary_id
CDR0000598878
Identifier Type: -
Identifier Source: org_study_id