Universal Genetic Testing Versus Guidelines-Directed Testing for Germline Pathogenic Variants Among Non-Western Patients With Breast Cancer

NCT ID: NCT04920656

Last Updated: 2025-03-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-04-01

Study Completion Date

2025-02-01

Brief Summary

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The study aims to examinethe pattern and frequency of pathogenic variants among all newly diagnosed breast cancer patients in a genetically distinct population. Additionally, the uptake rate of "cascade family screening" , frequency of pathogenic variants and barriers against testing will be studied.

Detailed Description

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Conditions

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Breast Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Breast cancer patients

All adult patients with a confirmed diagnosis of breast cancer, aged 18 or older at time of cancer diagnosis, will be invited to participate.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Adult patient, age ≥ 18 years at time of cancer diagnosis
* Pathology proven diagnosis of breast cancer (including DCIS); any stage. (prior history of cancer is allowed)
* Willingness to participate
* Signed consent form.

Exclusion Criteria

\- Major psychiatric disorder (defined as: patients followed by a psychiatrist and on antipsychotic medications
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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King Hussein Cancer Center

OTHER

Sponsor Role lead

Responsible Party

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Hikmat Abdel-Razeq

Professor, Chairman of department of medicine, Chief Medical officer, Deputy Director General

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Hikmat Abdel-Razeq

Role: PRINCIPAL_INVESTIGATOR

King Hussein Cancer Center

Locations

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King Hussein Cancer Center

Amman, Amman Governorate, Jordan

Site Status

Countries

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Jordan

Other Identifiers

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20 KHCC 202

Identifier Type: -

Identifier Source: org_study_id

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