Combined Breast Cancer Risk Study

NCT ID: NCT03067389

Last Updated: 2019-01-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

553 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-02-06

Study Completion Date

2019-01-08

Brief Summary

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A prospective, non-interventional study in women 18 to 84 years of age. Subjects will provide a sample for genetic testing and information about their medical and family history. The results of the genetic test will be combined with clinical data to validate a method of predicting breast cancer risk.

Detailed Description

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This is a prospective, non- interventional study. Women presenting at imaging centers for routine breast cancer screening or breast cancer diagnostic assessment and who provide written informed consent will undergo genetic testing. Subjects will also provide information about their personal medical and cancer history and family cancer history. The results of the genetic test will be combined with the subject's clinical information, family history, and a risk assessment model to validate a new method of predicting breast cancer.

Conditions

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Hereditary Cancer

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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History of invasive breast cancer

Subjects with a diagnosis of invasive breast cancer within the past 12 months will provide a blood or saliva sample for genetic diagnostic testing and provide information about their personal medical and cancer history and family cancer history.

Diagnostic test

Intervention Type DIAGNOSTIC_TEST

Genetic diagnostic test

No history of invasive breast cancer

Subjects with no history of breast cancer will provide a blood or saliva sample for genetic diagnostic testing and provide information about their personal medical and cancer history and family cancer history.

Diagnostic test

Intervention Type DIAGNOSTIC_TEST

Genetic diagnostic test

Interventions

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Diagnostic test

Genetic diagnostic test

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

Women without breast cancer:

* 18 to 84 years of age
* Western/Northern European, Central/Eastern European, or Ashkenazi ancestry
* No history of invasive breast cancer

Women with a history of breast cancer:

* 18 to 84 years of age
* Western/Northern European, Central/Eastern European, or Ashkenazi ancestry
* Pathologically confirmed invasive breast cancer diagnosed within the past 12 months

Exclusion Criteria

* Unwilling to provide written informed consent
* Women with history of ductal carcinoma in situ (DCIS).
* Patient has had a prior breast biopsy, exclusive of a breast biopsy diagnostic of breast cancer, that showed either hyperplasia, atypical hyperplasia, lobular carcinoma in situ (LCIS), or the specific histologic result is unknown to the patient
Minimum Eligible Age

18 Years

Maximum Eligible Age

84 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Myriad Genetic Laboratories, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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John Holmsn, MD

Role: STUDY_DIRECTOR

Myriad Genetics, Inc.

Locations

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The Breast Center of Northwest Arkansas

Fayetteville, Arkansas, United States

Site Status

Bethesda Health

Boynton Beach, Florida, United States

Site Status

Cuda Women's Health Center

Hyannis, Massachusetts, United States

Site Status

Elizabeth Wende Breast Care

Rochester, New York, United States

Site Status

Countries

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United States

Other Identifiers

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HCP-018

Identifier Type: -

Identifier Source: org_study_id

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