Dose-effect of SSR180575 in Diabetic Neuropathy

NCT ID: NCT00502515

Last Updated: 2017-08-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

309 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-07-31

Study Completion Date

2009-02-28

Brief Summary

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The primary objective of this sudy is to assess the effect of two doses of SSR180575 on the rate of regeneration of epidermal nerve fibers following denervation of the epidermal layer with capsaicin in patients with diabetes mellitus and mild peripheral neuropathy. Secondary objectives are to explore the efficacy of SSR180575 on clinical assessment, nerve function measures and to assess the tolerability and safety of SSR180575. The treatment period is 6 months.

Detailed Description

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Conditions

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Diabetic Neuropathies

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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25 mg SSR180575

orally once daily for 24 weeks

Group Type EXPERIMENTAL

SSR180575

Intervention Type DRUG

Oral, once daily dosing

100 mg SSR180575

orally once daily for 24 weeks

Group Type EXPERIMENTAL

SSR180575

Intervention Type DRUG

Oral, once daily dosing

Placebo

orally once daily for 24 weeks

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Oral, once daily dosing

Interventions

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SSR180575

Oral, once daily dosing

Intervention Type DRUG

Placebo

Oral, once daily dosing

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients diagnosed with Diabetes Mellitus, type I or II, treated or untreated
* Diabetic neuropathy treated or untreated

Exclusion Criteria

* Patients with unstable glycemic control
* Patients who have been hospitalized for a diabetes complication in the 3 months prior to randomization
* Patients with peripheral neuropathy attributable to any cause other than diabetes
* Non-measurable sural nerve sensory response on nerve conduction studies
* Amputation of any part of lower extremity
* Patients with a history of myocardial infarction or known coronary artery disease
* Grade III or IV heart failure on New York Heart Association criteria

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sanofi

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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ICD CSD

Role: STUDY_DIRECTOR

Sanofi

Locations

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Sanofi-Aventis Administrative Office

Bridgewater, New Jersey, United States

Site Status

Countries

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United States

Other Identifiers

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PDY5807

Identifier Type: -

Identifier Source: org_study_id

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