The DIEP-Flap as a Model of Ischemia-Reperfusion

NCT ID: NCT00482469

Last Updated: 2009-01-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

45 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-04-30

Study Completion Date

2008-11-30

Brief Summary

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It is our goal to study the mechanism of ischemia-reperfusion injury. Our DIEP-operation is actually a clinical model of ischemia-reperfusion. Ischemia-reperfusion injury has never been directly studied in a human, clinical model of autologous transplant.

Detailed Description

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Conditions

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Ischemia-Reperfusion

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* patient is undergoing a DIEP-breast reconstruction, unilateral as well as bilateral
* is aged 18 years or older

Exclusion Criteria

* diabetes mellitus
* diseases of the kidneys
* diseases of the liver
* patients who are taking immunosuppressants
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Maastricht University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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University Hospital Maastricht

Principal Investigators

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René R Van der Hulst, MD, PhD

Role: STUDY_CHAIR

Maastricht University Hospital

Marieke GW Van den Heuvel, MD

Role: PRINCIPAL_INVESTIGATOR

Maastricht University Hospital

Locations

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Department of Plastic and Reconstructive surgery, Maastricht University Hospital

Maastricht, , Netherlands

Site Status

Countries

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Netherlands

References

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van den Heuvel MG, Bast A, Haenen GR, Ambergen AW, Mermans JF, van der Hulst RR. The role of antioxidants in ischaemia-reperfusion in a human DIEP flap model. J Plast Reconstr Aesthet Surg. 2012 Dec;65(12):1706-11. doi: 10.1016/j.bjps.2012.06.010. Epub 2012 Jul 11.

Reference Type DERIVED
PMID: 22789619 (View on PubMed)

van den Heuvel MG, Mermans JF, Ambergen AW, van der Hulst RR. Perfusion of the deep inferior epigastric perforator flap measured by laser Doppler imager. Ann Plast Surg. 2011 Jun;66(6):648-53. doi: 10.1097/SAP.0b013e3181e37bc8.

Reference Type DERIVED
PMID: 21233705 (View on PubMed)

Other Identifiers

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MEC 07-2-004

Identifier Type: -

Identifier Source: org_study_id

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