The Perioperative Value of Platelet Counts in Predicting Outcome After Liver Transplantation

NCT ID: NCT01711957

Last Updated: 2012-10-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-01-31

Study Completion Date

2013-01-31

Brief Summary

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Recent experimental and clinical studies have shown that platelets play a critical role in liver ischemia and regeneration. Thrombocytopenia, a frequent and potentially serious condition in liver transplantation (LT) recipients, was shown to be associated with postoperative morbidity and mortality after partial hepatectomy.

The investigators aim at evaluating whether postoperative low platelet counts are indicators of short- and long-term outcomes after liver transplantation.

Detailed Description

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Conditions

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Complication Death

Keywords

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Complications Mortality Liver transplantation Platelet count Survival

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Liver disease and liver transplantation

Patient with end stage liver disease and/or primary liver tumor undergoing liver transplantation

Liver transplantation

Intervention Type PROCEDURE

Standardized technique of liver transplantation Organ procurement follow the rules of the Swiss transplant society

Interventions

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Liver transplantation

Standardized technique of liver transplantation Organ procurement follow the rules of the Swiss transplant society

Intervention Type PROCEDURE

Other Intervention Names

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Orthotopic liver transplantation (OLT) Cadaveric-donor liver transplantation

Eligibility Criteria

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Inclusion Criteria

* Age \>18 years old
* End stage liver disease
* Cadaveric-donor liver transplantation

Exclusion Criteria

* Age \<18 years old
* Pregnancy
* Living-related liver transplantation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Zurich

OTHER

Sponsor Role lead

Responsible Party

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Dimitri Aristotle Raptis

MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mickael Lesurtel, M.D., PhD

Role: STUDY_DIRECTOR

University of Zurich

Pierre-Alain Clavien, M.D., PhD

Role: STUDY_CHAIR

University of Zurich

Dimitri A. Raptis, M.D., MSc

Role: PRINCIPAL_INVESTIGATOR

University of Zurich

Emmanuel Melloul, M.D.

Role: PRINCIPAL_INVESTIGATOR

University of Zurich

Locations

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University Hospital Zurich, Department of Visceral Surgery and Transplantation

Zurich, Canton of Zurich, Switzerland

Site Status

Countries

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Switzerland

References

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Lesurtel M, Raptis DA, Melloul E, Schlegel A, Oberkofler C, El-Badry AM, Weber A, Mueller N, Dutkowski P, Clavien PA. Low platelet counts after liver transplantation predict early posttransplant survival: the 60-5 criterion. Liver Transpl. 2014 Feb;20(2):147-55. doi: 10.1002/lt.23759. Epub 2013 Nov 21.

Reference Type DERIVED
PMID: 24123804 (View on PubMed)

Other Identifiers

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EK-1487

Identifier Type: -

Identifier Source: org_study_id