Aortic Valve Replacement With Trifecta(TM)

NCT ID: NCT00475709

Last Updated: 2019-02-19

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

1022 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-06-30

Study Completion Date

2012-01-31

Brief Summary

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To confirm the clinical safety and effectiveness of the Trifecta valve.

Detailed Description

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The clinical investigation is a multi-center, multi-country, prospective, non-randomized, observational study designed to evaluate the safety and effectiveness of the Trifecta valve.

Conditions

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Aortic Valve Insufficiency Regurgitation, Aortic Valve Aortic Valve Incompetence Aortic Valve Stenosis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Trifecta Aortic Heart Valve

All subjects enrolled into the study are implanted with the Trifecta Aortic Heart Valve.

Group Type EXPERIMENTAL

Trifecta Aortic Heart Valve

Intervention Type DEVICE

Surgical replacement of the aortic valve with the Trifecta Aortic Heart Valve.

Interventions

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Trifecta Aortic Heart Valve

Surgical replacement of the aortic valve with the Trifecta Aortic Heart Valve.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Requires aortic valve replacement (heart surgery such as bypass is allowed at the same time).
* Legal age.
* Signed informed consent prior to surgery.
* Willing to complete all follow-up requirements.

Exclusion Criteria

* Pregnant or nursing women.
* Have already had a valve replaced other than the aortic valve.
* Needs another valve replaced.
* Cannot return for required follow-up visits.
* Have active endocarditis.
* Acute preoperative neurological event (such as a stroke).
* Renal dialysis.
* History of substance abuse within one year, or a prison inmate.
* Participating in another study.
* Life expectancy less than two years.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Medical Devices

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hartzell Schaff, MD

Role: PRINCIPAL_INVESTIGATOR

Mayo Clinic

Locations

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USC Keck School of Medicine, Dept. of Cardiothoracic Surgery, USC University Hospital

Los Angeles, California, United States

Site Status

Sarasota Memorial Hospital/Clinical Research Center

Sarasota, Florida, United States

Site Status

Loyola University Medical Center

Maywood, Illinois, United States

Site Status

William Beaumont Hospital

Royal Oak, Michigan, United States

Site Status

Abbott Northwestern Hospital

Minneapolis, Minnesota, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

NYU Medical Center

New York, New York, United States

Site Status

Columbia University Medical Center

New York, New York, United States

Site Status

Mission Hospitals

Asheville, North Carolina, United States

Site Status

Duke University Medical Center

Durham, North Carolina, United States

Site Status

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Site Status

University of Pennsylvania Health System

Philadelphia, Pennsylvania, United States

Site Status

Main Line Health Heart Center

Wynnewood, Pennsylvania, United States

Site Status

Vanderbilt Medical Center

Nashville, Tennessee, United States

Site Status

Cardiothoracic and Vascular Surgeons

Austin, Texas, United States

Site Status

Baylor College of Medicine

Houston, Texas, United States

Site Status

Intermountain Medical Center

Murray, Utah, United States

Site Status

Aurora St. Luke's Medical Center

Milwaukee, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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CS0501

Identifier Type: -

Identifier Source: org_study_id

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