Coronary and Structural Interventions - Transcatheter Aortic Valve Replacement

NCT ID: NCT02162069

Last Updated: 2020-04-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

843 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-06-30

Study Completion Date

2018-12-31

Brief Summary

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To evaluate the long-term results after transcatheter aortic valve replacement

Detailed Description

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Patients with transcatheter aortic valve replacement are followed for 5 years to demonstrate efficacy and safety.

Conditions

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Aortic Valve Stenosis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

TAVR
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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transcatheter aortic valve replacement

Patients receive transcatheter aortic valve replacement.

Group Type EXPERIMENTAL

CE certified transcatheter ( aortic valve replacement)

Intervention Type DEVICE

Patients receive a transcatheter aortic valve replacement with CE certified transcatheter aortic valves.

Interventions

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CE certified transcatheter ( aortic valve replacement)

Patients receive a transcatheter aortic valve replacement with CE certified transcatheter aortic valves.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* aortic valve stenosis
* transcatheter aortic valve replacement

Exclusion Criteria

* no written informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Ulm

OTHER

Sponsor Role lead

Responsible Party

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Jochen Wohrle

Prof. Dr. Jochen Wöhrle

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jochen Wöhrle, MD

Role: PRINCIPAL_INVESTIGATOR

University of Ulm, Ulm, Germany

Locations

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University of Ulm

Ulm, , Germany

Site Status

Countries

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Germany

References

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Seeger J, Gonska B, Otto M, Rottbauer W, Wohrle J. Cerebral Embolic Protection During Transcatheter Aortic Valve Replacement Significantly Reduces Death and Stroke Compared With Unprotected Procedures. JACC Cardiovasc Interv. 2017 Nov 27;10(22):2297-2303. doi: 10.1016/j.jcin.2017.06.037. Epub 2017 Sep 13.

Reference Type BACKGROUND
PMID: 28917515 (View on PubMed)

Seeger J, Kapadia SR, Kodali S, Linke A, Wohrle J, Haussig S, Makkar R, Mehran R, Rottbauer W, Leon M. Rate of peri-procedural stroke observed with cerebral embolic protection during transcatheter aortic valve replacement: a patient-level propensity-matched analysis. Eur Heart J. 2019 May 1;40(17):1334-1340. doi: 10.1093/eurheartj/ehy847.

Reference Type RESULT
PMID: 30590554 (View on PubMed)

Vernikouskaya I, Bertsche D, Rottbauer W, Rasche V. Deep learning-based framework for motion-compensated image fusion in catheterization procedures. Comput Med Imaging Graph. 2022 Jun;98:102069. doi: 10.1016/j.compmedimag.2022.102069. Epub 2022 May 13.

Reference Type DERIVED
PMID: 35576863 (View on PubMed)

Seeger J, Gonska B, Rottbauer W, Wohrle J. New generation devices for transfemoral transcatheter aortic valve replacement are superior compared with last generation devices with respect to VARC-2 outcome. Cardiovasc Interv Ther. 2018 Jul;33(3):247-255. doi: 10.1007/s12928-017-0477-6. Epub 2017 Jun 22.

Reference Type DERIVED
PMID: 28643214 (View on PubMed)

Seeger J, Gonska B, Rottbauer W, Wohrle J. Outcome With the Repositionable and Retrievable Boston Scientific Lotus Valve Compared With the Balloon-Expandable Edwards Sapien 3 Valve in Patients Undergoing Transfemoral Aortic Valve Replacement. Circ Cardiovasc Interv. 2017 Jun;10(6):e004670. doi: 10.1161/CIRCINTERVENTIONS.116.004670.

Reference Type DERIVED
PMID: 28566290 (View on PubMed)

Seeger J, Gonska B, Rodewald C, Rottbauer W, Wohrle J. Impact of suture mediated femoral access site closure with the Prostar XL compared to the ProGlide system on outcome in transfemoral aortic valve implantation. Int J Cardiol. 2016 Nov 15;223:564-567. doi: 10.1016/j.ijcard.2016.08.193. Epub 2016 Aug 17.

Reference Type DERIVED
PMID: 27561160 (View on PubMed)

Wohrle J, Gonska B, Rodewald C, Seeger J, Scharnbeck D, Rottbauer W. Transfemoral Aortic Valve Implantation with the New Edwards Sapien 3 Valve for Treatment of Severe Aortic Stenosis-Impact of Valve Size in a Single Center Experience. PLoS One. 2016 Mar 22;11(3):e0151247. doi: 10.1371/journal.pone.0151247. eCollection 2016.

Reference Type DERIVED
PMID: 27003573 (View on PubMed)

Other Identifiers

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CSI TAVR 1.0

Identifier Type: -

Identifier Source: org_study_id

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