Multicenter Study Evaluating the Efficacy of an Intervention Aimed At Reducing the Length of Stay After Transfemoral Transcatheter Aortic Valve Implantation

NCT ID: NCT04503655

Last Updated: 2024-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

1842 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-12-16

Study Completion Date

2022-02-09

Brief Summary

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Since the first implantation of a percutaneous aortic bioprosthesis (TAVI) in 2002 (Cribier et al. Circulation 2002), TAVI occupies an increasing place in the management of aortic stenosis (AR) . Initially reserved for inoperable patients at high surgical risk, TAVI is also recommended in patients at intermediate risk, especially when a femoral approach (TF) is possible (Baumgartner et al. Eur Heart J. 2017).

Currently, there is no recommendation regarding length of stay after TAVI and practices are extremely heterogeneous. Despite the growing experience of centers, better patient selection and a reduction in complications, the length of stay after TAVI remains very high in France.

Faced with the great disparity observed between the centers, efforts are necessary to educate the centers in order to further reduce the length of stay after TF-TAVI. The aim of the study is to evaluate the effectiveness of an intervention based on training teams to reduce the length of stay after TF-TAVI.

Detailed Description

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Conditions

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Aortic Valve Stenosis Cardiovascular Diseases

Keywords

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TAVI Aortic valve stenosis Lenght-of-stay Medico-economy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

In this study, there is a randomization of the participating centres in two groups.
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Intervention group

The randomized centres in this group will be follow a training dedicated on implementation of "organizational" and "therapeutic" measures (for prevention and management of complications) to reduce lenght-of-stay after TF TAVI.

Group Type EXPERIMENTAL

Training

Intervention Type OTHER

Training dedicated on implementation of "organizational" and "therapeutic" measures (for prevention and management of complications) to reduce lenght-of-stay after TF TAVI.

Control group

The randomized centres in this group will not change their practices.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Training

Training dedicated on implementation of "organizational" and "therapeutic" measures (for prevention and management of complications) to reduce lenght-of-stay after TF TAVI.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Patient over 18 years of age;
2. Patient hospitalized for TF-TAVI
3. Patient affiliated or benefiting from a health insurance scheme
4. Patient having read and understood the information letter and having signed the consent form.

Exclusion Criteria

1. Proven pregnant woman (positive urine pregnancy test) or breastfeeding or absence of effective contraception (as defined by the WHO) or postmenopausal woman without confirmation diagnosis obtained (amenorrhea not medically induced for at least 12 months before the initiation visit) ; 1
2. Person deprived of their liberty by an administrative or judicial decision or person placed under the protection of justice / guardianship or curatorship
3. History of illness or psychological or sensory abnormality likely to prevent the subject from fully understanding the conditions required for participating in the protocol or preventing him from giving his informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Rouen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU d'Amiens

Amiens, , France

Site Status

CHU d'Angers

Angers, , France

Site Status

CHU de Bordeaux

Bordeaux, , France

Site Status

CHU de Brest

Brest, , France

Site Status

CHU de Caen

Caen, , France

Site Status

Hôpital privé Saint Martin

Caen, , France

Site Status

CHU de Clermont-Ferrand

Clermont-Ferrand, , France

Site Status

Hôpital Henri Mondor (AP-HP)

Créteil, , France

Site Status

CHU de Dijon

Dijon, , France

Site Status

CHU de Grenoble

Grenoble, , France

Site Status

CHU de Limoges

Limoges, , France

Site Status

Hôpital privé Jacques Cartier

Massy, , France

Site Status

Clinique du Millénaire

Montpellier, , France

Site Status

Hôpital Bichat, AP-HP

Paris, , France

Site Status

Hôpital Européen Georges Pompidou (AP-HP)

Paris, , France

Site Status

CHU de Poitiers

Poitiers, , France

Site Status

CHU de Strasbourg

Strasbourg, , France

Site Status

CHU de Toulouse

Toulouse, , France

Site Status

Clinique Pasteur

Toulouse, , France

Site Status

Clinique Saint Gatien

Tours, , France

Site Status

Countries

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France

References

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Durand E, Beziau-Gasnier D, Michel M, Iung B, Tchetche D, Bonnet G, Lhermusier T, Gilard M, Souteyrand G, Bouleti C, Ohlmann P, Lefevre T, Beygui F, Chassaing S, Chevreul K, Eltchaninoff H; FAST-TAVI II; STOP-AS investigators. Reducing length of stay after transfemoral transcatheter aortic valve implantation: the FAST-TAVI II trial. Eur Heart J. 2024 Mar 14;45(11):952-962. doi: 10.1093/eurheartj/ehae081.

Reference Type DERIVED
PMID: 38437633 (View on PubMed)

Other Identifiers

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2020/0185/HP

Identifier Type: -

Identifier Source: org_study_id