The Safety and Effectiveness of Transcatheter Aortic Valve Raplacemet in Intermediate Risk Patients With Bicuspid Aortic Stenosis

NCT ID: NCT03163329

Last Updated: 2018-01-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-01

Study Completion Date

2024-10-31

Brief Summary

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Previous trials have shown that TAVR was a noninferior alternative to surgery in patients with severe aortic stenosis at intermediate surgical risk. However, patients with congenital bicuspid valve have been excluded in those trials. The purpose of this trial is to determine the safety and effectiveness of TAVR in intermediate-risk patients with bicuspid aortic valve stenosis.

Detailed Description

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Conditions

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Aortic Valve Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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TAVR group

Group Type EXPERIMENTAL

TAVR

Intervention Type PROCEDURE

Transcatheter Aortic Valve Replacement

SAVR group

Group Type ACTIVE_COMPARATOR

SAVR

Intervention Type PROCEDURE

Surgical Aortic Valve Replacement

Interventions

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TAVR

Transcatheter Aortic Valve Replacement

Intervention Type PROCEDURE

SAVR

Surgical Aortic Valve Replacement

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Severe, calcific bicuspid aortic stenosis.
2. Heart team agrees the patient has a risk of operative mortality and has an STS \<8 and \>3.
3. The study patient has been informed of the nature of the study, agrees to its provisions and has provided written informed consent as approved by the Institutional Review Board (IRB) of the respective clinical site.

Exclusion Criteria

1. Ilio-femoral vessel characteristics that would preclude safe placement of the introducer sheath.
2. Evidence of an acute myocardial infarction ≤ 1 month (30 days) before randomization.
3. Severe aortic regurgitation (\>3+).
4. Severe mitral regurgitation (\>3+).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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China National Center for Cardiovascular Diseases

OTHER_GOV

Sponsor Role lead

Responsible Party

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Yongjian Wu

Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Yong-jian Wu, M.D, Ph.D

Role: CONTACT

0086-10-88396780

Other Identifiers

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AS-20170520

Identifier Type: -

Identifier Source: org_study_id

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