Red Cell Storage Duration and Outcomes in Cardiac Surgery

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

3942 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-04-30

Study Completion Date

2019-01-16

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to determine whether length of storage of RBC is related to postoperative morbid outcomes in patients undergoing cardiac surgery.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Balancing Risk: Red Blood Cell Transfusion Strategies In Cardiac Surgery

NCT00651573

Anemia

COMPLETED NA

Red Cell Storage Duration Study

NCT00991341

Cardiac Surgery Erythrocyte Transfusion

COMPLETED PHASE3

Blood Products in Cardiac Surgery

NCT02068755

Anemia Renal Impairment Thrombocytopenia

COMPLETED

Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease

NCT00071032

Anemia Hematologic Diseases Cardiovascular Diseases +5 more

COMPLETED PHASE3

Clinical Impact of Red Cell Storage Age

NCT05482737

RBC Transfusions

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Subjects undergoing cardiac surgery will be randomized into one of two groups. Group A will receive transfused blood that has storage duration less than 14 days. Group B will receive transfused blood with a storage duration of more than 20 days.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Blood Transfusion Cardiac Surgery

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Prolonged RBC storage

Transfusion with oldest available matching RBCs.

Group Type ACTIVE_COMPARATOR

Prolonged RBC storage

Intervention Type BIOLOGICAL

Transfusion with oldest available matching RBCs

Short RBC storage

Transfusion with youngest available matching RBCs.

Group Type ACTIVE_COMPARATOR

Short RBC storage

Intervention Type BIOLOGICAL

Transfusion with youngest available matching RBCs

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Prolonged RBC storage

Transfusion with oldest available matching RBCs

Intervention Type BIOLOGICAL

Short RBC storage

Transfusion with youngest available matching RBCs

Intervention Type BIOLOGICAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* All primary and reoperative adult cardiac surgical patients undergoing cardiopulmonary bypass for coronary artery bypass grafting, coronary artery bypass grafting with a valve procedure, isolated valve procedures, ascending aortic aneurysm or dissection repair alone or combined with CABG and valve procedures

Exclusion Criteria

* Age less than 18 years
* Descending thoracic aortic aneurysm repairs
* Left or right ventricular assist devices
* Those unable to receive blood for religious reasons

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No