Risk Stratification of Non ST Elevation ACS With Computed Tomographic Angiography (REACT)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

107 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-09-30

Study Completion Date

2010-12-31

Brief Summary

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The purpose of this project is to examine the effectiveness of computed tomographic angiography (CTA) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). People who are hospitalized with this situation often require an angiogram to assess the heart and its arteries.

Recent advancements in technology have enabled CTA to clearly define coronary artery anatomy with great accuracy and to guide treatment strategies in select patient populations. We are investigating that CTA may be used, as an alternative to conventional angiograms, for the risk stratification of patients with high risk NSTE-ACS.

Patients eligible for the study will be high risk NSTE-ACS and awaiting an angiogram. Enrolled patients will undergo CTA prior to the angiogram. With each CTA the patient will be injected with a small dose of an X-ray dye and will be asked to lie still on the "scanning bed" for a period of 5-10 minutes.

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Detailed Description

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Conditions

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Acute Coronary Syndrome Non-ST-Elevation Myocardial Infarction Unstable Angina

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Outcome Assessors

Interventions

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Computed Tomographic Angiography

CT scan

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* High risk ACS

1. Angina \[accelerating pattern or prolonged episode (\> 20 minutes) or recurrent episode at rest or with minimal effort within preceding 24 hours\]; and (13)
2. Elevated Troponin - T (≥0.1 ug/L) or ECG changes consistent with ischemia \[ST depression ≥ 0.1 mV, transient ST segment elevation ≥ 0.1 mV (\< 20 minutes)\]) (11;13)
* Planned conventional invasive coronary angiography

Exclusion Criteria

* Age \< 18 years or lack of consent
* Renal Insufficiency (GFR \< 60 ml/min)
* Allergy to contrast agent
* Refractory angina requiring urgent/emergent coronary angiography (as per treating physician)
* Contraindication to radiation exposure (e.g. pregnancy)
* Uncontrolled HR
* Previous CABG or PCI/Stent
* Atrial fibrillation, frequent atrial or ventricular ectopy (\> 1 / minute)
* Unable to perform 20 second breath-hold

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No