N-Terminal Pro-brain Natriuretic Peptide Hormone and Persistent Pulmonary Hypertension
NCT ID: NCT00443859
Last Updated: 2016-07-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
10 participants
OBSERVATIONAL
2007-02-28
2008-09-30
Brief Summary
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Detailed Description
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Brain natriuretic peptide (BNP) is a cardiac hormone that is secreted from cardiac myocytes and cardiac fibroblasts. Upon activation, the prohormone is cleaved into a biologically active BNP and an inactive N-terminal proBNP (NT-proBNP). BNP and NT-proBNP levels are increasingly being used for diagnostic purpose in adults and have been correlated to adult pulmonary hypertension. Multiples studies have been performed to determine normal values for NT-proBNP in the pediatric population. One study measured NT-proBNP levels in umbilical cord blood during the second trimester and at delivery of uncomplicated pregnancies and determined normal reference values of NT-proBNP. It is thought that NT-proBNP has potential for use in term infants with PPHN.
The objective of this research is to correlate NT-proBNP levels to left ventricular dysfunction in term infants with PPHN. Secondarily, we want to assess the possible use of NT-proBNP to predict response to inhaled nitric oxide and the ability to successfully wean off inhaled nitric oxide.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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PPHN
Infants with persistent pulmonary hypertension (PPHN)
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* clinical diagnosis of PPHN
Exclusion Criteria
6 Months
ALL
Yes
Sponsors
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Thomas Jefferson University
OTHER
Christiana Care Health Services
OTHER
Responsible Party
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Principal Investigators
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Euming Chong, MD
Role: PRINCIPAL_INVESTIGATOR
Christiana Hospital / Thomas Jefferson University Hospital
Constance Andrejko, DO
Role: PRINCIPAL_INVESTIGATOR
Christiana Hospital / Thomas Jefferson University Hospital
Locations
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Christiana Hospital
Newark, Delaware, United States
Thomas Jefferson University
Philadelphia, Pennsylvania, United States
Countries
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Other Identifiers
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CCC 27004
Identifier Type: -
Identifier Source: org_study_id
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