Vitamin D Supplementation to Patients With Type 2 Diabetes

NCT ID: NCT00400491

Last Updated: 2008-05-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-06-30

Study Completion Date

2007-09-30

Brief Summary

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The purpose of the study is to evaluate if supplementation with vitamin D in a dose of 40.000 IU per week will result in improved metabolic control in patients with type 2 diabetes.

Detailed Description

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The purpose of the study is to evaluate if supplementation with vitamin D in a dose of 40.000 IU per week will result in improved metabolic control in patients with type 2 diabetes.

We will include 70 patients with type 2 diabetes. They will be treated with 40.000 IU cholecalciferol per week (or placebo) for 6 months. Metabolic control will be evaluated with measurements of glycated hemoglobin, home glucose measurements, and fasting blod glucose and serum insulin. Only subjects using insulin at bedtime combined with metformin during the day will be included.

Conditions

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Type 2 Diabetes

Keywords

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diabetes insulin glycated hemoglobin cholecalciferol vitamin D

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

Group Type EXPERIMENTAL

Cholecalciferol (vitamin D)

Intervention Type DRUG

Cholecalciferol capsule 20.000 IU twice per week for 6 months

2

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo capsule twice a week, identical to the cholecalciferol capsules

Interventions

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Cholecalciferol (vitamin D)

Cholecalciferol capsule 20.000 IU twice per week for 6 months

Intervention Type DRUG

Placebo

Placebo capsule twice a week, identical to the cholecalciferol capsules

Intervention Type DRUG

Other Intervention Names

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vitamin D

Eligibility Criteria

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Inclusion Criteria

* Type 2 diabetes for at least 1 year
* age 21-75 years
* long-acting insulin at bedtime
* metformin during the day
* for women of child bearing age use of reliable method of birth control

Exclusion Criteria

* serum creatinine above 130 umol/l for men and above 110 for women
* systolic blood pressure \> 175 or diastolic \> 104 mmHg
* heart disease
* serum calcium \> 2.54 mmol/l
* history of renal stones
Minimum Eligible Age

21 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Tromso

OTHER

Sponsor Role lead

Responsible Party

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University of Tromso

Principal Investigators

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Rolf Jorde, Professor

Role: PRINCIPAL_INVESTIGATOR

University of Tromsø, Tromsø

Locations

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Clinical Research Unit, University Hospital of North Norway

Tromsø, Tromsø, Norway

Site Status

Countries

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Norway

Other Identifiers

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EUDRACT-2006-000177-30

Identifier Type: -

Identifier Source: org_study_id