Why Are Patients With Absence Seizures Absent? A Brain Imaging Study

NCT ID: NCT00393666

Last Updated: 2016-01-26

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 180 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2006-09-30
• Study Completion Date: 2015-09-30

Brief Summary

Our study examines which different brain regions are involved in child absence seizures and how they are related to attention and cognition.

Detailed Description

The fundamental mechanisms of altered brain function and impaired attention in childhood absence epilepsy (CAE) are not known. Absence seizures consist of brief 5-10 seconds episodes of unresponsiveness, associated with a 3-4 Hz "spike-wave" discharge on electroencephalogram (EEG). CAE affects 10-15% of children with epilepsy. In addition to the deficit during seizures, many children also suffer from milder attention impairment between absence episodes, which may not be due entirely to medications. Impaired attention during and between absence seizures has a major negative impact on patient quality of life due to deficits in school performance, potential for injuries, and social stigma.

Recent studies suggest that impaired cognition in so-called "generalized" absence seizures may, in fact, depend on dysfunction in specific brain networks. Our central hypothesis is: abnormal function in focal brain regions, such as the anterior cingulate/medial prefrontal cortex and medial thalamus, causes impaired attention both during and between seizures in CAE. If confirmed, this may lead to innovative regional therapies targeted at improving impaired attention in CAE. Specifically, we hope to determine which specific cortical and sub-cortical networks are selectively involved when patients show impaired attention. Using simultaneous EEG and functional magnetic resonance imaging (fMRI), we will determine which brain regions are involved in absence seizures while using a continuous performance task (CPT) to test attention vigilance in the same patients. A few neuropsychology tests will then follow. Patients will be reimbursed $100 as well as all travel and parking expenses.

For more information, please visit www.yalecae.com

Conditions

Childhood Absence Epilepsy

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Confirmed diagnosis of childhood absence epilepsy or juvenile absence epilepsy
• No other serious health problems or neurological problems
• 6 years or older

Exclusion Criteria

• No history of myoclonic or tonic-clonic seizures

• Minimum Eligible Age: 6 Years
• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Institutes of Health (NIH)

NIH

Sponsor Role: collaborator

Yale University

OTHER

Sponsor Role: lead

Responsible Party

Hal Blumenfeld

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Hal Blumenfeld, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Yale University

Michiro Negishi, PhD

Role: STUDY_DIRECTOR

Diagnostic Radiology

R. Todd Constable, PhD

Role: STUDY_DIRECTOR

Yale University

Jennifer Guo, MS

Role: STUDY_DIRECTOR

Yale University

Locations

Yale University School of Medicine, Neurology Department

New Haven, Connecticut, United States

Countries

United States

Other Identifiers

HIC # 18514

Identifier Type: -

Identifier Source: secondary_id

NIH R01 NS055829

Identifier Type: -

Identifier Source: org_study_id