Study to Evaluate a 13-valent Pneumococcal Conjugate Vaccine in Infants

NCT ID: NCT00366678

Last Updated: 2012-08-15

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

613 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-10-31

Study Completion Date

2008-11-30

Brief Summary

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The purpose of this study is to assess the safety, tolerability and immunogenicity of a 13-valent pneumococcal conjugate (13vPnC) vaccine compared to Prevenar (7vPnC), when given concomitantly with routine pediatric vaccines in France.

Detailed Description

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Conditions

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Vaccines, Pneumococcal

Keywords

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Safety Vaccine

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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13-valent pneumococcal conjugate vaccine

13-valent pneumococcal conjugate vaccine

Group Type EXPERIMENTAL

13-valent pneumococcal conjugate vaccine

Intervention Type BIOLOGICAL

Single 0.5 mL dose given at 2, 3, 4, and 12 months of age.

Pentavac

Intervention Type DRUG

The Pentavac was administered by intramuscular injection 0.5 ml into the anterolateral thigh muscle of the right leg at 2, 3, and 4 months (infant series) and 12 months of age (toddler dose).

7-valent pneumococcal conjugate vaccine

7-valent pneumococcal conjugate vaccine

Group Type ACTIVE_COMPARATOR

7-valent pneumococcal conjugate vaccine

Intervention Type BIOLOGICAL

Single 0.5 mL dose given at 2, 3, 4, and 12 months of age.

Pentavac

Intervention Type DRUG

The Pentavac was administered by intramuscular injection 0.5 ml into the anterolateral thigh muscle of the right leg at 2, 3, and 4 months (infant series) and 12 months of age (toddler dose).

Interventions

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13-valent pneumococcal conjugate vaccine

Single 0.5 mL dose given at 2, 3, 4, and 12 months of age.

Intervention Type BIOLOGICAL

7-valent pneumococcal conjugate vaccine

Single 0.5 mL dose given at 2, 3, 4, and 12 months of age.

Intervention Type BIOLOGICAL

Pentavac

The Pentavac was administered by intramuscular injection 0.5 ml into the anterolateral thigh muscle of the right leg at 2, 3, and 4 months (infant series) and 12 months of age (toddler dose).

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy 2-month-old infants.
* Available for the entire study period.

Exclusion Criteria

· Known contraindication to vaccines.
Minimum Eligible Age

42 Days

Maximum Eligible Age

98 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Wyeth is now a wholly owned subsidiary of Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Monitor

Role: STUDY_DIRECTOR

Wyeth is now a wholly owned subsidiary of Pfizer

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For France, [email protected]

Locations

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Albi, , France

Site Status

Amiens, , France

Site Status

Ancenis, , France

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Blanquefort, , France

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Bondues, , France

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Bordeaux, , France

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Brest, , France

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Châlons-en-Champagne, , France

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Créteil, , France

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Dijon, , France

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Draguignan, , France

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Essey-lès-Nancy, , France

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Écully, , France

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Floirac, , France

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Fréjus, , France

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Garges-lès-Gonesse, , France

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Illkirch-Graffenstaden, , France

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Joué-lès-Tours, , France

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Le Havre, , France

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Le Plessis-Trévise, , France

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Le Pontet, , France

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Les Lilas, , France

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Les Sables-d'Olonne, , France

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Libourne, , France

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Lingolsheim, , France

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Lyon, , France

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Lyon, , France

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Marcq-en-Barœul, , France

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Maromme, , France

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Moûtiers, , France

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Nancy, , France

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Nice, , France

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Nogent-sur-Marne, , France

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Oullins, , France

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Paris, , France

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Rouen, , France

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Strasbourg, , France

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Strasbourg, , France

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Thionville, , France

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Tours, , France

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Tresses Melac, , France

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Vandœuvre-lès-Nancy, , France

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Vaulx-en-Velin, , France

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Villeneuve-d'Ascq, , France

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Vitry-sur-Seine, , France

Site Status

Countries

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France

Other Identifiers

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6096A1-008

Identifier Type: -

Identifier Source: org_study_id