Study Evaluating 13-valent Pneumococcal Conjugate Vaccine (13vPnC) in Healthy Children Aged 15 Months to 17 Years

NCT ID: NCT00761631

Last Updated: 2013-07-31

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

1200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-12-31

Study Completion Date

2010-07-31

Brief Summary

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This open-label, multicenter study is designed to evaluate the safety, tolerability and immunogenicity of 13-valent pneumococcal conjugate vaccine in healthy children aged more than 15 months up to less than 18 years.

Detailed Description

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Conditions

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Healthy Subjects

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Single

Open label

Group Type EXPERIMENTAL

13 valent pneumococcal conjugate vaccine

Intervention Type BIOLOGICAL

Intramuscular injection of 0.5mL at visit 1 and visit 2 for group 1 and and visit 1 for groups 2, 3, and 4.

Interventions

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13 valent pneumococcal conjugate vaccine

Intramuscular injection of 0.5mL at visit 1 and visit 2 for group 1 and and visit 1 for groups 2, 3, and 4.

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Male or female subjects \>15months to \<18years in good health, available for entire study period and reachable by phone, parents/legal guardian able and willing to complete all study procedures, written documentation from health professional showing prior vaccination with Prevnar (except for group 4).

Group 4 only:

* Negative urine pregnancy test for female subjects who are menstruating.

Exclusion Criteria

* Previous reaction or contra-indication to pneumococcal vaccine or vaccine related component , bleeding diathesis, received blood transfusion or blood related products, immune deficiency,congenital malformation.

Group 4 only:

* Previous vaccination with Prevnar or any other pneumococcal vaccine.
* Pregnant or breastfeeding adolescent females.
Minimum Eligible Age

15 Months

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Benton, Arkansas, United States

Site Status

Pfizer Investigational Site

Fayetteville, Arkansas, United States

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Jonesboro, Arkansas, United States

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Little Rock, Arkansas, United States

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Fountain Valley, California, United States

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Loma Linda, California, United States

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Torrance, California, United States

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Tampa, Florida, United States

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Marietta, Georgia, United States

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DeKalb, Illinois, United States

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Louisville, Kentucky, United States

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Saint Paul, Minnesota, United States

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Lebanon, New Hampshire, United States

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Whitehouse Station, New Jersey, United States

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Rochester, New York, United States

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Cary, North Carolina, United States

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Bismarck, North Dakota, United States

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Fargo, North Dakota, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Tulsa, Oklahoma, United States

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Philadelphia, Pennsylvania, United States

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Clarksville, Tennessee, United States

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Galveston, Texas, United States

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San Antonio, Texas, United States

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Murray, Utah, United States

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Salt Lake City, Utah, United States

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South Jordan, Utah, United States

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Vienna, Virginia, United States

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Pfizer Investigational Site

Vancouver, Washington, United States

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Pfizer Investigational Site

Monroe, Wisconsin, United States

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Countries

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United States

References

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Frenck R Jr, Thompson A, Senders S, Harris-Ford L, Sperling M, Patterson S, Devlin C, Jansen KU, Gruber WC, Emini EA, Scott DA, Gurtman A. 13-Valent pneumococcal conjugate vaccine in older children and adolescents either previously immunized with or naive to 7-valent pneumococcal conjugate vaccine. Pediatr Infect Dis J. 2014 Feb;33(2):183-9. doi: 10.1097/INF.0000000000000056.

Reference Type DERIVED
PMID: 24136369 (View on PubMed)

Frenck R Jr, Thompson A, Yeh SH, London A, Sidhu MS, Patterson S, Gruber WC, Emini EA, Scott DA, Gurtman A; 3011 Study Group. Immunogenicity and safety of 13-valent pneumococcal conjugate vaccine in children previously immunized with 7-valent pneumococcal conjugate vaccine. Pediatr Infect Dis J. 2011 Dec;30(12):1086-91. doi: 10.1097/INF.0b013e3182372c6a.

Reference Type DERIVED
PMID: 21983216 (View on PubMed)

Related Links

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Other Identifiers

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6096A1-3011

Identifier Type: -

Identifier Source: org_study_id

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