A Study Assessing 13-valent Pneumococcal Conjugate Vaccine in Healthy Chinese Subjects

NCT ID: NCT01531322

Last Updated: 2018-09-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

72 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-10-31

Study Completion Date

2012-01-31

Brief Summary

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This study will assess the safety and tolerability of a single dose of 13-valent Pneumococcal Conjugate Vaccine for approximately 1 month after vaccination sequentially in healthy Chinese adults aged 18 through 55 years, followed by children aged 3 through 5 years, and then infants aged approximately 2 months.

Detailed Description

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Conditions

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Pneumococcal Infection

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Group 1

Adults aged 18 through 55 years (before the fifty sixth birthday)

Group Type EXPERIMENTAL

13-valent Pneumococcal Conjugate Vaccine

Intervention Type BIOLOGICAL

suspension in prefilled syringe for intramuscular injection, 0.5 mL, only one dose

Group 2

Children aged 3 through 5 years (before the sixth birthday)

Group Type EXPERIMENTAL

13-valent Pneumococcal Conjugate Vaccine

Intervention Type BIOLOGICAL

suspension in prefilled syringe for intramuscular injection, 0.5 mL, only one dose

Group 3

Infants aged approximately 2 months (42 to 98 days)

Group Type EXPERIMENTAL

13-valent Pneumococcal Conjugate Vaccine

Intervention Type BIOLOGICAL

suspension in prefilled syringe for intramuscular injection, 0.5 mL, only one dose

Interventions

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13-valent Pneumococcal Conjugate Vaccine

suspension in prefilled syringe for intramuscular injection, 0.5 mL, only one dose

Intervention Type BIOLOGICAL

13-valent Pneumococcal Conjugate Vaccine

suspension in prefilled syringe for intramuscular injection, 0.5 mL, only one dose

Intervention Type BIOLOGICAL

13-valent Pneumococcal Conjugate Vaccine

suspension in prefilled syringe for intramuscular injection, 0.5 mL, only one dose

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

1. Age at the time of enrollment is:

* 18 through 55 years (before the fifty sixth birthday) for Group 1.
* 3 through 5 years (before the sixth birthday) for Group 2.
* 42 to 98 days for Group 3.
2. Healthy subject as determined by medical history, physical examination, and judgment of the investigator.

Exclusion Criteria

* Previous vaccination with licensed or investigational pneumococcal vaccine.
* Previous anaphylactic reaction to any vaccine or vaccine-related component.
* Contraindication to vaccination with pneumococcal vaccine.
Minimum Eligible Age

42 Days

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Huaian, Jiangsu, China

Site Status

Pfizer Investigational Site

Nanjing, Jiangsu, China

Site Status

Countries

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China

References

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Zhu F, Hu Y, Liang Q, Young M Jr, Zhou X, Chen Z, Liang JZ, Gruber WC, Scott DA. Safety and tolerability of 13-valent pneumococcal conjugate vaccine in healthy Chinese adults, children and infants. Ther Adv Drug Saf. 2015 Dec;6(6):206-11. doi: 10.1177/2042098615613985.

Reference Type DERIVED
PMID: 26668712 (View on PubMed)

Related Links

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Other Identifiers

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6096A1-1000

Identifier Type: -

Identifier Source: secondary_id

B1851046

Identifier Type: -

Identifier Source: org_study_id

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