Study Evaluating a 13-valent Pneumococcal Conjugate Vaccine in Preterm Compared to Term Infants.

NCT ID: NCT01193335

Last Updated: 2017-05-11

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-10-31

Study Completion Date

2014-01-31

Brief Summary

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The purpose of this study is to describe the safety, tolerability, and immunogenicity of a 2,3,4 and 12 month schedule of the 13-valent pneumococcal conjugate vaccine when given to preterm infants with concomitant vaccines, compared to infants born at term.There will be a follow-up phase to assess the persistence of the antibody response at 24 and 36 months of age.

Detailed Description

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Conditions

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13-valent Pneumococcal Vaccine Premature Birth Immunization Safety

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Group 1: Preterm infants

Infant born at \< 37 weeks of gestation.

Group Type ACTIVE_COMPARATOR

13-valent pneumococcal conjugate vaccine

Intervention Type BIOLOGICAL

13-valent pneumococcal conjugate vaccine will be administered at 2, 3, 4 and 12 months of age.

Group 2: Term infants

Infants born at ≥ 37 weeks of gestation

Group Type ACTIVE_COMPARATOR

13-valent pneumococcal conjugate vaccine

Intervention Type BIOLOGICAL

13-valent pneumococcal conjugate vaccine will be administered at 2, 3, 4 and 12 months of age.

Interventions

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13-valent pneumococcal conjugate vaccine

13-valent pneumococcal conjugate vaccine will be administered at 2, 3, 4 and 12 months of age.

Intervention Type BIOLOGICAL

13-valent pneumococcal conjugate vaccine

13-valent pneumococcal conjugate vaccine will be administered at 2, 3, 4 and 12 months of age.

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Healthy Infants between 42 and 98 days of age (approximately 2 months) at the time of enrollment.

Exclusion Criteria

* Previous vaccination with pneumococcal vaccine,Haemophilus influenzae type B (Hib) conjugate vaccine, meningococcal type C conjugate vaccine, or diphtheria, tetanus, pertussis, or poliovirus vaccines.
* Previous anaphylactic reaction or allergy to any vaccine
* Contraindication to vaccination
* Known or suspected immune deficiency or immune suppression
* Major known congenital malformation or serious chronic disorder
* Significant neurological disorder
* Participation to another study
Minimum Eligible Age

42 Days

Maximum Eligible Age

98 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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NZOZ "HIPOKRATES-II" Sp. z o.o.

Krakow, , Poland

Site Status

Hanna Czajka Indywidualna Praktyka Specjalistyczna Lekarska

Krakow, , Poland

Site Status

SP ZOZ Wojewodzki Specjalistyczny Szpital im. W. Bieganskiego w Lodzi

Lodz, , Poland

Site Status

Specjalistyczny ZOZ nad Matka i Dzieckiem

Poznan, , Poland

Site Status

Szpital im. Sw. Jadwigi Slaskiej, Oddzial Pediatryczny

Trzebnica, , Poland

Site Status

Samodzielny Publiczny Szpital Kliniczny nr 1 we Wroclawiu

Wroclaw, , Poland

Site Status

Hospital Universitario de Santiago de Compostela

Santiago de Compostela, A Coruña, Spain

Site Status

Complejo Hospitalario DE Torrecardenas

Almería, Almeria, Spain

Site Status

Complexo Hospitalario Xeral Cies

Vigo, Pontevedra, Spain

Site Status

Hospital 12 de Octubre

Madrid, , Spain

Site Status

Hospital Universitario de La Paz

Madrid, , Spain

Site Status

Complejo Hospitalario de Navarra

Pamplona, , Spain

Site Status

Countries

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Poland Spain

References

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Martinon-Torres F, Wysocki J, Center KJ, Czajka H, Majda-Stanislawska E, Omenaca F, Concheiro-Guisan A, Gimenez-Sanchez F, Szenborn L, Blazquez-Gamero D, Moreno-Galarraga L, Giardina PC, Sun G, Gruber WC, Scott DA, Gurtman A. Circulating Antibody 1 and 2 Years After Vaccination With the 13-Valent Pneumococcal Conjugate Vaccine in Preterm Compared With Term Infants. Pediatr Infect Dis J. 2017 Mar;36(3):326-332. doi: 10.1097/INF.0000000000001428.

Reference Type DERIVED
PMID: 27902652 (View on PubMed)

Martinon-Torres F, Czajka H, Center KJ, Wysocki J, Majda-Stanislawska E, Omenaca F, Bernaola Iturbe E, Blazquez Gamero D, Concheiro-Guisan A, Gimenez-Sanchez F, Szenborn L, Giardina PC, Patterson S, Gruber WC, Scott DA, Gurtman A. 13-valent pneumococcal conjugate vaccine (PCV13) in preterm versus term infants. Pediatrics. 2015 Apr;135(4):e876-86. doi: 10.1542/peds.2014-2941. Epub 2015 Mar 16.

Reference Type DERIVED
PMID: 25780077 (View on PubMed)

Related Links

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Other Identifiers

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6096A1-4001

Identifier Type: OTHER

Identifier Source: secondary_id

2009-017332-41

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

B1851037

Identifier Type: -

Identifier Source: org_study_id

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