Safety and Compliance of Taking Mesalamine Once a Day in Pediatric Patients

NCT ID: NCT00349388

Last Updated: 2019-01-29

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

1 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-07-31

Study Completion Date

2011-01-31

Brief Summary

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To determine whether once a day administration of Mesalamine is at least as safe and efficacious and administration of multiple doses a day in preventing clinical relapse of ulcerative colitis in children and adolescence.

Detailed Description

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Is taking total dose in mg/kg once a day, as safe as taking total dose divided in mg/kg spreadout during the day in preventing clinical relapse of ulcerative colitis in children and adolescence.

Conditions

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Ulcerative Colitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Asacol once a day dosing

Asacol total dose in mg/kg given once a day

Group Type EXPERIMENTAL

Asacol

Intervention Type DRUG

Asacol is given once a day versus twice or three times a day

Asacol BID/TID dosing

Asacol total dose split BID or TID

Group Type ACTIVE_COMPARATOR

Asacol

Intervention Type DRUG

Asacol is given once a day versus twice or three times a day

Interventions

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Asacol

Asacol is given once a day versus twice or three times a day

Intervention Type DRUG

Other Intervention Names

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Mesallamine

Eligibility Criteria

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Inclusion Criteria

* Ages 6 to 18 years,
* Must be able to swallow tablets, and
* Biopsy proven ulcerative colitis

Exclusion Criteria

* Allergy or hypersensitivity to Mesalamine or other salicylates
* Use of rectal medications
Minimum Eligible Age

6 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Procter and Gamble

INDUSTRY

Sponsor Role collaborator

Annette Langseder

OTHER

Sponsor Role lead

Responsible Party

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Annette Langseder

Joel Rosh, MD

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Joel Rosh, MD

Role: PRINCIPAL_INVESTIGATOR

Atlantic Health System

Locations

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Morristown Memorial Hospital/Goyerb Children's Hospital

Morristown, New Jersey, United States

Site Status

Countries

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United States

Other Identifiers

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R05-11-010

Identifier Type: -

Identifier Source: org_study_id

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