A Double Blind Study for the Treatment of Acute Ulcerative Colitis

NCT ID: NCT00350415

Last Updated: 2013-04-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

772 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-06-30

Study Completion Date

2007-05-31

Brief Summary

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A Double-blind, Randomized, 6-week, Parallel-group Design Clinical trial to assess the Safety and Efficacy of Asacol 4.8 g/day (800 mg mesalamine tablet) versus Asacol 2.4 g/day (400 mg mesalamine tablet) for the Treatment of Moderately Active Ulcerative Colitis (ASCEND III).

Detailed Description

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This is a double-blind, randomized, multi-center, multi-national, active-control study in patients who are experiencing a moderately active flare of UC. Patients will be randomly assigned to receive either Asacol 2.4 g/day (400 mg tablet) or Asacol 4.8 g/day (800 mg tablet) for 6 weeks. Patients will be randomized to one of the 2 treatment groups in a 1:1 ratio. The objective of the study is to evaluate the safety and efficacy of Asacol 4.8 g/day (800 mg tablet) compared to Asacol 2.4 g/day (400 mg tablet) in this patient population. Following successful screening, patients will be randomized to one of the two treatment arms. Patients will be evaluated after 6 weeks of treatment with an interim visit after 3 weeks.

Conditions

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Ulcerative Colitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

Asacol 2.4 g/day (400 mg tablet)

Group Type EXPERIMENTAL

Mesalamine

Intervention Type DRUG

Asacol 400g/day (400 mg tablet), oral, for 6 weeks

OR

Asacol 4,8 g/day (800 mg table), oral, for 6 weeks

2

Asacol 4,8 g/day (800 mg tablet), oral, for 6 weeks

Group Type ACTIVE_COMPARATOR

Mesalamine

Intervention Type DRUG

Asacol 400g/day (400 mg tablet), oral, for 6 weeks

OR

Asacol 4,8 g/day (800 mg table), oral, for 6 weeks

Interventions

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Mesalamine

Asacol 400g/day (400 mg tablet), oral, for 6 weeks

OR

Asacol 4,8 g/day (800 mg table), oral, for 6 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients 18-75 years with a confirmed diagnosis of moderately active flare of ulcerative colitis.
* Female patients need to be postmenopausal or using adequate contraception.

Exclusion Criteria

* Patients with isolated proctitis
* Patients with comorbidities or an investigative or commercialized treatments confounding interpretation of study results or compromising patients' safety in the trial.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Warner Chilcott

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Piotr Krzeski, MD

Role: STUDY_DIRECTOR

Procter and Gamble

Locations

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Alabaster, Alabama, United States

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Birmingham, Alabama, United States

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Tucson, Arizona, United States

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Fayetteville, Arkansas, United States

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Little Rock, Arkansas, United States

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Anaheim, California, United States

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Burbank, California, United States

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Encinitas, California, United States

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Los Angeles, California, United States

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Los Angeles, California, United States

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Mission Hills, California, United States

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Orange, California, United States

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Pasadena, California, United States

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Roseville, California, United States

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Sacramento, California, United States

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San Carlos, California, United States

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San Francisco, California, United States

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Lakewood, Colorado, United States

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Littleton, Colorado, United States

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Hamden, Connecticut, United States

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DeLand, Florida, United States

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Harbor Village, Florida, United States

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Hollywood, Florida, United States

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Jacksonville, Florida, United States

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Panama City, Florida, United States

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Zephyrhills, Florida, United States

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Atlanta, Georgia, United States

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Savannah, Georgia, United States

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Arlington Heights, Illinois, United States

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Chicago, Illinois, United States

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Topeka, Kansas, United States

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Louisville, Kentucky, United States

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Baton Rouge, Louisiana, United States

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Shreveport, Louisiana, United States

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Baltimore, Maryland, United States

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Chevy Chase, Maryland, United States

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Reisterstown, Maryland, United States

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Boston, Massachusetts, United States

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Columbia, Michigan, United States

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Minneapolis, Minnesota, United States

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Rochester, Minnesota, United States

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Tupelo, Mississippi, United States

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Kansas City, Missouri, United States

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St Louis, Missouri, United States

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Omaha, Nebraska, United States

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Scottsbluff, Nebraska, United States

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Egg Harbor, New Jersey, United States

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Binghamton, New York, United States

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Garden City, New York, United States

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Great Neck, New York, United States

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Huntington, New York, United States

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New York, New York, United States

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Rochester, New York, United States

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Troy, New York, United States

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Charlotte, North Carolina, United States

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Wilmington, North Carolina, United States

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Bismarck, North Dakota, United States

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Fargo, North Dakota, United States

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Akron, Ohio, United States

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Cincinnati, Ohio, United States

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Dayton, Ohio, United States

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Warren, Ohio, United States

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Portland, Oregon, United States

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Beaver Falls, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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York, Pennsylvania, United States

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Columbia, South Carolina, United States

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Kingsport, Tennessee, United States

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Memphis, Tennessee, United States

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Nashville, Tennessee, United States

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Austin, Texas, United States

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San Antonio, Texas, United States

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Murray, Utah, United States

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Ogden, Utah, United States

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Burlington, Vermont, United States

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Chesapeake, Virginia, United States

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Redmond, Washington, United States

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Milwaukee, Wisconsin, United States

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Gornel, Gormel, Belarus

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Hrodna, Grodnenskaya, Belarus

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Minsk, Minsk City, Belarus

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Vitebsk, Vitebsk Oblast, Belarus

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Edmonton, Alberta, Canada

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Abbotsford, British Columbia, Canada

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Vancouver, British Columbia, Canada

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Guelph, Ontario, Canada

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Hamilton, Ontario, Canada

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London, Ontario, Canada

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Ottawa, Ontario, Canada

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Toronto, Ontario, Canada

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Lévis, Quebec, Canada

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Longheuil, Quebec, Canada

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Montreal, Quebec, Canada

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Québec, Quebec, Canada

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Québec, Quebec, Canada

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Rimouski, Quebec, Canada

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Saskatoon, Saskatchewan, Canada

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Zagreb, City of Zagreb, Croatia

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Rijeka, Rijeka, Croatia

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Kralove, Kralove, Czechia

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Pavlov, Pavlov, Czechia

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Prague, Praha 2, Czechia

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Strakonice, Strakonice, Czechia

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Ústí nad Labem, Usti nad Labem, Czechia

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Tallinn, Tallinn, Estonia

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Tartu, Tartu, Estonia

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Argenti Dome Ter, Argenti Dome Ter, Hungary

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Budapest, Budapest, Hungary

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Nagyerdei Krt, Nagyerdei Krt, Hungary

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Riga, Rīga, Latvia

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Kaunas, Kaunas County, Lithuania

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Panevezys, Panevėžys, Lithuania

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Santariskiu, Vilnius County, Lithuania

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Bydgoszcz, Bydgoszcz, Poland

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Częstochowa, Czestochowa, Poland

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Krakow, Krakow, Poland

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Pruszków, Pruszkow, Poland

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Sopot, Sopot, Poland

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Warsaw, Warszawa, Poland

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Wtoctawek, Wtoctawek, Poland

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Lodz, Łódź Voivodeship, Poland

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San Juan, , Puerto Rico

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Bucharest, București, Romania

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Cluj-Napoca, Cluj-napoca, Romania

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Iași, Iaşi, Romania

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Moscow, Mowcow, Russia

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Nizhny Novgorod, Nizhny Novgorod Oblast, Russia

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Saint Petersburg, Sankt-Peterburg, Russia

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Belgrade, Beograd, Serbia

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Novi Sad, Novi Sad, Serbia

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Kharkiv, Kharkivs’ka Oblast’, Ukraine

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Kyiv, Kyiv Oblast, Ukraine

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Zabolotnogo, Odesa Oblast, Ukraine

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Simpheropol, Simpheropol, Ukraine

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Zaporizhzhya, Zaporizhzhya, Ukraine

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Countries

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United States Belarus Canada Croatia Czechia Estonia Hungary Latvia Lithuania Poland Puerto Rico Romania Russia Serbia Ukraine

Related Links

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Other Identifiers

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2006444

Identifier Type: -

Identifier Source: org_study_id

NCT00336440

Identifier Type: -

Identifier Source: nct_alias

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