Randomized Trial of a Liberal Versus a Restrictive Transfusion Strategy in Elderly Cardiac Surgery Patients
NCT ID: NCT00318227
Last Updated: 2017-08-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
73 participants
INTERVENTIONAL
2004-06-21
2010-02-23
Brief Summary
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Two postoperative transfusion strategies:
1. Liberal - transfused when Hgb is \<100g/L
2. Restrictive - transfused when Hgb is \<70g/L
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Liberal Red cell transfusion arm
Transfusion if Hgb \<100g/L
Blood Transfusion
Blood transfusion will be administered when the transfusion trigger is met.
Restrictive Red Cell transfusion
Transfusion if Hgb \<70g/L
Blood Transfusion
Blood transfusion will be administered when the transfusion trigger is met.
Interventions
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Blood Transfusion
Blood transfusion will be administered when the transfusion trigger is met.
Eligibility Criteria
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Inclusion Criteria
* Initial postoperative hemoglobin level 70-90g/L
Exclusion Criteria
* Patients with preoperative hemoglobin concentrations \<100g/L
* Patients who require emergency re-operation
* Patients with intraoperative or postoperative bleeding diathesis
* Patients with postoperative clinical instability (eg. low output state)
* Patients in whom insertion of an intra-aortic balloon pump is required
70 Years
90 Years
ALL
No
Sponsors
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London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
OTHER
Responsible Party
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Principal Investigators
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Mary Lee Myers, MD FRCSC
Role: PRINCIPAL_INVESTIGATOR
London Health Sciences Centre/University of Western Ontario
Robin Varghese, MD MS FRCSC
Role: PRINCIPAL_INVESTIGATOR
London Health Sciences Centre/University of Western Ontario
Locations
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London Health Sciences Centre - University Campus
London, Ontario, Canada
Countries
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References
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Carson JL, Stanworth SJ, Dennis JA, Fergusson DA, Pagano MB, Roubinian NH, Turgeon AF, Valentine S, Trivella M, Doree C, Hebert PC. Transfusion thresholds and other strategies for guiding red blood cell transfusion. Cochrane Database Syst Rev. 2025 Oct 20;10:CD002042. doi: 10.1002/14651858.CD002042.pub6.
Other Identifiers
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9540
Identifier Type: -
Identifier Source: secondary_id
R-03-043
Identifier Type: -
Identifier Source: org_study_id
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