GALLEX 4 - Long-Term Extension Study to Evaluate Tesaglitazar Therapy in Patients With Type 2 Diabetes

NCT ID: NCT00300105

Last Updated: 2008-03-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

400 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-10-31

Study Completion Date

2006-12-31

Brief Summary

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This is a parallel-group, multi-center, long-term extension study from the GALLANT 4 study to monitor the safety and tolerability of oral tesaglitazar compared with glibenclamide in patients with type 2 diabetes for up to 100 weeks of treatment. The total duration, including treatment and follow-up, is 103 weeks.

Detailed Description

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Conditions

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Type 2 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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Tesaglitazar

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Provision of a written informed consent
* Men or women who are \>=18 years of age
* Female patients: postmenopausal, hysterectomized, or if of childbearing potential, using a reliable method of birth control
* Completed the last two visits of randomized treatment period in GALLANT 4

Exclusion Criteria

* Type 1 diabetes
* New York Heart Association heart failure Class III or IV
* Treatment with chronic insulin
* History of hypersensitivity or intolerance to any peroxisome proliferator-activated receptor agonist (like Actos or Avandia), fenofibrate, metformin or 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin)
* History of drug-induced myopathy or drug-induced creatine kinase elevation, liver enzyme elevations, neutropenia (low white blood cells)
* Creatinine levels above twice the normal range
* Creatine kinase above 3 times the upper limit of normal
* Previous enrollment in this long-term extension study
* Any clinically significant abnormality identified on physical examination, laboratory tests or electrocardiogram, which in the judgment of the investigator would compromise the patient's safety or successful participation in the clinical study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Principal Investigators

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AstraZeneca Galida Medical Science Director, MD

Role: STUDY_DIRECTOR

AstraZeneca

Locations

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Research Site

Hasselt, , Belgium

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Liège, , Belgium

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Sint-Gillis-Waas, , Belgium

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Steenokkerzeel, , Belgium

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Shatin, , Hong Kong

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Balatonfüred, , Hungary

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Budapest, , Hungary

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Kaposvár, , Hungary

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Kecskemét, , Hungary

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Székesfehérvár, , Hungary

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Gubbio, , Italy

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Milan, , Italy

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Perugia, , Italy

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Piacenza, , Italy

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Reggio Emilia, , Italy

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Udine, , Italy

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Kubang Kerian, Kelantan, Malaysia

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Kuala Lumpur, , Malaysia

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Makati City, , Philippines

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Manila, , Philippines

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Pasig, , Philippines

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Krakow, , Poland

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Lublin, , Poland

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Płock, , Poland

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Torun, , Poland

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Tychy, , Poland

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Warsaw, , Poland

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£ód?, , Poland

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Banská Bystrica, , Slovakia

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Bratislava, , Slovakia

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Ilava, , Slovakia

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Košice, , Slovakia

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Kysucké Nové Mesto, , Slovakia

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Lučenec, , Slovakia

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Ľubochňa, , Slovakia

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Nitra, , Slovakia

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Prešov, , Slovakia

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Trnava, , Slovakia

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Johannesburg, Gauteng, South Africa

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Cape Town, , South Africa

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Durban, , South Africa

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Bangkok, , Thailand

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Countries

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Belgium Hong Kong Hungary Italy Malaysia Philippines Poland Slovakia South Africa Thailand

Other Identifiers

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EudraCT No 2004-005243-97

Identifier Type: -

Identifier Source: secondary_id

D6160C00047

Identifier Type: -

Identifier Source: org_study_id

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