GALLANT 22 Tesaglitazar vs. Placebo

NCT ID: NCT00252837

Last Updated: 2008-03-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

475 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-04-30

Study Completion Date

2006-12-31

Brief Summary

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This is a 24-week randomized, double-blind, parallel-group, multi-center, placebo-controlled study of tesaglitazar (0.5 and 1 mg) in patients with type 2 diabetes, not adequately controlled on diet and lifestyle advice alone during the run-in period. The study comprises a 6-week single-blind placebo run-in period, followed by 24-week treatment period and a 3-week follow-up period.

The study design of GALLANT 2 is identical to GALLANT 22; the blinded study data from GALLANT 2 will be transferred to the GALLANT 22 database and will be analyzed together with the data from GALLANT 22 clinical study.

Detailed Description

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Conditions

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Type 2 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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Tesaglitazar

Intervention Type DRUG

Dietary and Lifestyle counseling

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Provision of a written informed consent
* Men or women who are \>=18 years of age
* Female patients: postmenopausal, hysterectomized, or if of childbearing potential, using a reliable method of birth control
* Diagnosed with type 2 diabetes
* Treated with diet alone or treatment with a single oral antidiabetic agent or low doses of two oral antidiabetic agents
* Drug-naïve (ie, no use of antidiabetic drug\[s\], for at least 24 weeks prior to visit 1).

Exclusion Criteria

* Type 1 diabetes
* New York Heart Association heart failure Class III or IV
* Treatment with chronic insulin
* History of hypersensitivity or intolerance to any peroxisome proliferator-activated receptor agonist (like Actos or Avandia), fenofibrate, metformin or 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin)
* History of drug-induced myopathy or drug-induced creatine kinase elevation, liver enzyme elevations, neutropenia (low white blood cells)
* Creatinine levels above twice the normal range
* Creatine kinase above 3 times the upper limit of normal
* Received any investigational product in other clinical studies within 12 weeks
* Any clinically significant abnormality identified on physical examination, laboratory tests or electrocardiogram, which in the judgment of the investigator would compromise the patient's safety or successful participation in the clinical study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Principal Investigators

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AstraZeneca Galida Medical Science Director, MD

Role: STUDY_DIRECTOR

AstraZeneca

Locations

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Research Site

Adelaide, , Australia

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Cairns, , Australia

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Gosford, , Australia

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Keswick, , Australia

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Kippa-Ring, , Australia

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Melbourne, , Australia

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Miranda, , Australia

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Nowra, , Australia

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Wollongong, , Australia

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Brno, , Czechia

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Hodonín, , Czechia

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Hradec Králové, , Czechia

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Pilsen, , Czechia

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Prague, , Czechia

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Příbram, , Czechia

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Semily, , Czechia

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Tábor, , Czechia

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Ústí nad Labem, , Czechia

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Paide, , Estonia

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Pärnu, , Estonia

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Tallinn, , Estonia

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Tartu, , Estonia

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Viljandi, , Estonia

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Angers, , France

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Briollay, , France

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Poitiers, , France

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Saint-Benoît, , France

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Saint-Ouen, , France

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Toulouse, , France

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Trélazé, , France

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Athens, , Greece

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Piraeus, , Greece

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Balatonfüred, , Hungary

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Budapest, , Hungary

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Kaposvár, , Hungary

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Kecskemét, , Hungary

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Székesfehérvár, , Hungary

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Daugavpils, , Latvia

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Jēkabpils, , Latvia

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Madona, , Latvia

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Riga, , Latvia

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Sigulda, , Latvia

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Talsi, , Latvia

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Valmiera, , Latvia

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Kaunas, , Lithuania

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Klaipėda, , Lithuania

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Panevezys, , Lithuania

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Vilnius, , Lithuania

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Aursmoen, , Norway

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Bergen, , Norway

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Enebakk, , Norway

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Fredrikstad, , Norway

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Haugesund, , Norway

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Hønefoss, , Norway

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Inderøy, , Norway

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Larvik, , Norway

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Lierskogen, , Norway

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Oslo, , Norway

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Rolvsøy, , Norway

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Cebu City, , Philippines

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Pasig, , Philippines

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Quezon City, , Philippines

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Katowice, Ochojec, Poland

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Bialystok, , Poland

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Bydgoszcz, , Poland

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Gdansk, , Poland

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Krakow, , Poland

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Lodz, , Poland

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Lublin, , Poland

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Olsztyn, , Poland

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Poznan, , Poland

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Radom, , Poland

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Rzeszów, , Poland

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Sopot, , Poland

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Szczecin, , Poland

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Toruñ, , Poland

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Tychy, , Poland

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Warsaw, , Poland

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Wroclaw, , Poland

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Zabrze, , Poland

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Zielona Góra, , Poland

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Belgrade, , Serbia and Montenegro

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Dolný Kubín, , Slovakia

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Levice, , Slovakia

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Lučenec, , Slovakia

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Ľubochňa, , Slovakia

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Nové Zámky, , Slovakia

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Považská Bystrica, , Slovakia

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Šahy, , Slovakia

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Trenčín, , Slovakia

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Veľký Meder, , Slovakia

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Žilina, , Slovakia

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Åmål, , Sweden

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Borås, , Sweden

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Gothenburg, , Sweden

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Mölndal, , Sweden

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Partille, , Sweden

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Skene, , Sweden

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Stenungsund, , Sweden

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Uddevalla, , Sweden

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Vänersborg, , Sweden

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Countries

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Australia Czechia Estonia France Greece Hungary Latvia Lithuania Norway Philippines Poland Serbia and Montenegro Slovakia Sweden

Other Identifiers

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EudraCT No 2004-004374-90

Identifier Type: -

Identifier Source: secondary_id

D6160C00055

Identifier Type: -

Identifier Source: org_study_id

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