Combined Behavioral and Pharmacologic Treatment of Polydrug Abuse

NCT ID: NCT00292123

Last Updated: 2017-01-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

1999-06-30

Study Completion Date

2006-08-31

Brief Summary

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The primary goal of this study is to determine how contingency management can best be combined with standard or high doses of methadone to increase simultaneous abstinence from heroin and cocaine.

Detailed Description

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A study of people pmaintained on Methadone using contingency management

Conditions

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Opioid Dependence Cocaine Abuse

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Interventions

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Methadone

Intervention Type DRUG

Contingency Management

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Opioid dependence; cocaine use

Exclusion Criteria

* Medical or psychiatric conditions that would contraindicate participation in a methadone maintenance study; inability to give informed consent; inability to attend clinic seven days a week
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role lead

Responsible Party

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National Institute on Drug Abuse

Principal Investigators

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Kenzie Preston, PhD

Role: PRINCIPAL_INVESTIGATOR

NIFA Intramural Research Program

References

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Ghitza UE, Epstein DH, Preston KL. Contingency management reduces injection-related HIV risk behaviors in heroin and cocaine using outpatients. Addict Behav. 2008 Apr;33(4):593-604. doi: 10.1016/j.addbeh.2007.11.009. Epub 2007 Nov 17.

Reference Type RESULT
PMID: 18068905 (View on PubMed)

Willner-Reid J, Belendiuk KA, Epstein DH, Schmittner J, Preston KL. Hepatitis C and human immunodeficiency virus risk behaviors in polydrug users on methadone maintenance. J Subst Abuse Treat. 2008 Jul;35(1):78-86. doi: 10.1016/j.jsat.2007.08.011. Epub 2007 Oct 10.

Reference Type RESULT
PMID: 17931826 (View on PubMed)

Ghitza UE, Epstein DH, Schmittner J, Vahabzadeh M, Lin JL, Preston KL. Randomized trial of prize-based reinforcement density for simultaneous abstinence from cocaine and heroin. J Consult Clin Psychol. 2007 Oct;75(5):765-74. doi: 10.1037/0022-006X.75.5.765.

Reference Type RESULT
PMID: 17907858 (View on PubMed)

Ghitza UE, Epstein DH, Preston KL. Psychosocial functioning and cocaine use during treatment: strength of relationship depends on type of urine-testing method. Drug Alcohol Depend. 2007 Dec 1;91(2-3):169-77. doi: 10.1016/j.drugalcdep.2007.05.018. Epub 2007 Jul 10.

Reference Type RESULT
PMID: 17624688 (View on PubMed)

Heinz A, Epstein DH, Preston KL. Spiritual/Religious experiences and in-treatment outcome in an inner-city program for heroin and cocaine dependence. J Psychoactive Drugs. 2007 Mar;39(1):41-9. doi: 10.1080/02791072.2007.10399863.

Reference Type RESULT
PMID: 17523584 (View on PubMed)

Heinz AJ, Epstein DH, Schroeder JR, Singleton EG, Heishman SJ, Preston KL. Heroin and cocaine craving and use during treatment: measurement validation and potential relationships. J Subst Abuse Treat. 2006 Dec;31(4):355-64. doi: 10.1016/j.jsat.2006.05.009. Epub 2006 Aug 1.

Reference Type RESULT
PMID: 17084789 (View on PubMed)

Ghitza UE, Epstein DH, Preston KL. Nonreporting of cannabis use: Predictors and relationship to treatment outcome in methadone maintained patients. Addict Behav. 2007 May;32(5):938-49. doi: 10.1016/j.addbeh.2006.06.034. Epub 2006 Aug 1.

Reference Type RESULT
PMID: 16887281 (View on PubMed)

Other Identifiers

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NIDAIRP 326

Identifier Type: -

Identifier Source: org_study_id

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