Non-Abstinence Outcomes in Methamphetamine Use Disorder

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-14

Study Completion Date

2031-01-04

Brief Summary

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Reduced drug use is a clinically meaningful target for treatment development, but few studies have evaluated the positive impacts produced by this behavioral change, preventing adoption of this endpoint in clinical trials. The proposed research will fill that critical knowledge gap by demonstrating the biopsychosocial benefits of reduced methamphetamine use. These data will be used to change current accepted methamphetamine treatment endpoints and accelerate identification of therapies for methamphetamine use disorder.

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Detailed Description

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Conditions

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Methamphetamine Use Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Caregivers Outcome Assessors

Study Groups

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Control Group

This group will receive payment for providing urine samples throughout the trial.

Group Type NO_INTERVENTION

No interventions assigned to this group

Contingency Management Group

This group will receive payment for providing methamphetamine negative urine samples throughout the trial.

Group Type EXPERIMENTAL

Contingency Management

Intervention Type BEHAVIORAL

Subjects will receive payments for providing methamphetamine negative urine samples.

Interventions

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Contingency Management

Subjects will receive payments for providing methamphetamine negative urine samples.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* be age 18 years or older;
* self-report methamphetamine use in the week prior to screening;
* provide a methamphetamine-positive urine sample at screening;
* meet DSM-5 criteria for moderate-severe Methamphetamine Use Disorder (MUD);
* be seeking treatment for their methamphetamine use
* be able and willing to commit to the 12-week intervention, as well as the 12-week post-intervention follow-up
* Individuals who meet these criteria and are stably maintained on buprenorphine or methadone for Opioid Use Disorder (OUD) will also be eligible to participate.

Exclusion Criteria

* current or past medical or psychiatric illness (e.g., physical dependence on any drug other than buprenorphine requiring medically managed detoxification, unstable angina, uncontrolled cardiac arrhythmia, aortic stenosis, self-reported compromised immune function, severe diagnosis for a SUD other than MUD or treated OUD) that would interfere with study participation in the opinion of the study physicians
* poor venous access precluding blood draws

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No