Isoflavones and the Coronary Circulation in Men and Women With Coronary Artery Disease
NCT ID: NCT00287690
Last Updated: 2019-08-05
Study Results
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View full resultsBasic Information
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COMPLETED
PHASE2/PHASE3
71 participants
INTERVENTIONAL
1999-10-31
2003-08-18
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Genistein
Supro drink once daily for 3 days
Genistein
Drink taken once daily
Placebo
Drink identical to Supro but containing no genistein, once daily for 3 days
Placebo
Drink taken once daily
Interventions
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Genistein
Drink taken once daily
Placebo
Drink taken once daily
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Patients requiring diagnostic coronary angiography
* Presence of coronary artery disease on angiogram but with at least one non-obstructed (lesions \<70% narrowed compared with the adjacent normal part of the vessel) atheromatous vessel (confirmed at diagnostic cardiac catheterisation)
* Female patients must be postmenopausal (FSH\>40 IU/L)
* Willing to give informed, written consent
Exclusion Criteria
* Allergy to radiographic contrast media
* Sino-atrial disease or significant bradycardia
* Concomitant medication with persantin (dipyridamole) or theophyllines
* Asthma
* Hypertension
* Left ventricular hypertrophy or dysfunction (clinical/ECG/echo/CXR)
* Female patients with FSH\<40 IU/L (postmenopausal)
* Female patients currently taking hormone therapy, or who have taken hormone therapy in previous 6 months
* Unwilling to give written informed consent
* Participation in another study within previous 60 days
30 Years
75 Years
ALL
No
Sponsors
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Imperial College London
OTHER
Responsible Party
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Principal Investigators
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Peter Collins, MD, FRCP
Role: PRINCIPAL_INVESTIGATOR
Imperial College London
Locations
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Royal Brompton & Harefield NHS Trust
London, , United Kingdom
Countries
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Other Identifiers
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98-170
Identifier Type: -
Identifier Source: org_study_id
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