Attain StarFix™ Model 4195 Left Ventricular Lead

NCT ID: NCT00269230

Last Updated: 2008-11-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

441 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-07-31

Study Completion Date

2005-07-31

Brief Summary

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People who have abnormal heart beats, or whose heart does not beat on its own, may need an electronic device called a pacemaker or a defibrillator. Furthermore, people whose hearts have a reduced pumping ability may need a device are called cardiac resynchronization therapy (CRT) device. A CRT device is implanted surgically just under the skin in the upper chest area. This device then helps the heart beat at a regular rhythm by sending electrical signals (pacing) directly to the heart tissue through flexible wires called leads. The device may also be able to stop the heart from beating too fast. Three leads are implanted into the chambers of your heart. Two of the leads will be placed on the right side of your heart. The third lead is placed on the left side of your heart and is the lead being studied.

The purpose of this study is to evaluate the safety and efficacy of the Attain StarFixTM Model 4195 Left Ventricular (LV) Lead. This particular model lead has special characteristics that may help to better keep it in position once it is implanted into the left ventricle. It is also "steroid-eluting" which means that over time it slowly releases a small amount of medication into the heart tissue to help prevent too much swelling around the area it is implanted.

Detailed Description

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Conditions

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Heart Failure

Keywords

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cardiac resynchronization therapy, left ventricular Lead, Heart Failure

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Pacing Lead

Left ventricular pacing lead

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* QRS \> 130 ms (The QRS interval is a measurement of how the electrical signal involved in a heart beat travels, or is conducted, through the ventricles. A wide QRS (more than 120) suggests that there is a conduction problem, or block, in the ventricles.)
* Left Ventricular Ejection Fraction (EF) \< 35% (Ejection Fraction is a measurement of how well the left ventricle pumps blood out to the rest of the body. The higher the EF the more blood the ventricle is pumping.)
* Subject has moderate to severe heart failure despite medications

Exclusion Criteria

* Subjects with a previous lead in the left ventricle or previous implant attempt within 30 days of implant or ongoing complications from a previous unsuccessful attempt
* Subjects with chest pain or who have had a heart attack within the past month before enrollment in the study
* Subjects that have had certain surgeries on their heart within the past three months
* Subjects with chronic (permanent) fast heart beats in the upper chambers of the heart (atrial arrhythmias)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medtronic Cardiac Rhythm and Heart Failure

INDUSTRY

Sponsor Role lead

Responsible Party

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Medtronic CRDM

Principal Investigators

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Stuart W Adler II, MD

Role: PRINCIPAL_INVESTIGATOR

St. Paul Heart Clinic

Locations

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Long Beach, California, United States

Site Status

Palo Alto, California, United States

Site Status

Newark, Delaware, United States

Site Status

Jacksonville, Florida, United States

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Orlando, Florida, United States

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Atlanta, Georgia, United States

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Lexington, Kentucky, United States

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Grand Rapids, Michigan, United States

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Saginaw, Michigan, United States

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Saint Paul, Minnesota, United States

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St Louis, Missouri, United States

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Lincoln, Nebraska, United States

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Newark, New Jersey, United States

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Rochester, New York, United States

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Durham, North Carolina, United States

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Germantown, Tennessee, United States

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Nashville, Tennessee, United States

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Dallas, Texas, United States

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Temple, Texas, United States

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Milwaukee, Wisconsin, United States

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Calgary, Alberta, Canada

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Victoria, British Columbia, Canada

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London, Ontario, Canada

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Sainte-Foy, Quebec, Canada

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Milan, , Italy

Site Status

Countries

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United States Canada Italy

Other Identifiers

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234

Identifier Type: -

Identifier Source: org_study_id