Clinical Investigation of the Medtronic Concerto™ Device

NCT ID: NCT00268320

Last Updated: 2008-09-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

270 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-01-31

Study Completion Date

2007-07-31

Brief Summary

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Heart failure is a progressive disease that decreases the pumping action of the heart. This may cause a backup of fluid in the heart and may result in heart beat changes. When there are changes in the heart beat sometimes an implantable heart device is used to control the rate and rhythm of the heart beat. In certain heart failure cases, when the two lower chambers of the heart no longer beat in a coordinated manner, cardiac resynchronization therapy may be prescribed.

People who have a dangerously fast heart beat, or whose heart is at risk of stopping beating, may be in need of an electronic device called an implantable cardioverter defibrillator (ICD).

Atrial tachyarrhythmia (AT) is the name for rapid beats in the upper chambers of the heart. People with AT may experience symptoms such as heart palpitations (a racing or pounding feeling in the chest), shortness of breath, dizziness, fatigue or weakness.

The purpose of this study is to study an investigational implantable device containing Cardiac Resynchronization Therapy (CRT) and Implantable Cardioverter Defibrillator (ICD) therapies (CRT+ICD device) in subjects who are at significant risk of developing atrial tachyarrhythmias.

Detailed Description

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Conditions

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Congestive Heart Failure, Atrial Arrhythmia, Atrial Tachyarrhythmia, Atrial Fibrillation

Keywords

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congestive heart failure, atrial arrhythmia, cardiac resynchronization therapy, implantable cardioverter defibrillator

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Cardiac Resynchronization Therapy+Implantable Cardioverter Defibrillator

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subjects who require the implantation of an Implantable Cardioverter Defibrillator
* Subjects who have heart failure that severely limits daily activities (NYHA Class III) or Subjects who have severe heart failure and should always be resting (NYHA Class IV)
* Subjects with reduced heart pumping function (left ventricular ejection fraction ≤ 35%)

Exclusion Criteria

* Subjects who have constant atrial fibrillation (top chambers of the heart beat too fast continuously)
* Subjects who are post-heart transplant
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medtronic Cardiac Rhythm and Heart Failure

INDUSTRY

Sponsor Role lead

Principal Investigators

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Not required for IDE studies

Role:

Locations

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Anchorage, Alaska, United States

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Phoenix, Arizona, United States

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Santa Monica, California, United States

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Jacksonville, Florida, United States

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Orlando, Florida, United States

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Pensacola, Florida, United States

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Atlanta, Georgia, United States

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Evanston, Illinois, United States

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Fort Wayne, Indiana, United States

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Des Moines, Iowa, United States

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Brighton, Massachusetts, United States

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Detroit, Michigan, United States

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Saint Paul, Minnesota, United States

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Kansas City, Missouri, United States

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St Louis, Missouri, United States

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Newark, New Jersey, United States

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Albuquerque, New Mexico, United States

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Syracuse, New York, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Pittsburgh, Pennsylvania, United States

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West Reading, Pennsylvania, United States

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Charleston, South Carolina, United States

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Nashville, Tennessee, United States

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Austin, Texas, United States

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Fort Worth, Texas, United States

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Richmond, Virginia, United States

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Tacoma, Washington, United States

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Morgantown, West Virginia, United States

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Linz, , Austria

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Sankt Pölten, , Austria

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Copenhagen, , Denmark

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Aachen, , Germany

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Bernau, , Germany

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Bochum, , Germany

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Göttingen, , Germany

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Heidelberg, , Germany

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Münster, , Germany

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Pátrai, , Greece

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Negrar, Veneto, Italy

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Bologna, , Italy

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Tsukuba, Ibaraki, Japan

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Suita, Osaka, Japan

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Shinjuku-ku, Tokyo, Japan

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Eindhoven, , Netherlands

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Rotterdam, , Netherlands

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Oslo, , Norway

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Valencia, , Spain

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Basel, , Switzerland

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Southhampton, , United Kingdom

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Countries

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United States Austria Denmark Germany Greece Italy Japan Netherlands Norway Spain Switzerland United Kingdom

Other Identifiers

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230

Identifier Type: -

Identifier Source: org_study_id