Effect of Prevacid on Prostaglandin Levels in Patient With Stress Ulcer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-10-31

Study Completion Date

2007-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to measure the prostaglandin levels in patients with stress ulcer and the effect of Prevacid on prostaglandin levels in patients with stress ulcer.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Gastroprotective Agent Compliance in Patients at Risk Suffering From a Gastrointestinal(GI) Ulcer

NCT01215058

Gastrointestinal Hemorrhage Ulcer

WITHDRAWN

Evaluating the Efficacy of "Digestive Aid" in Functional Dyspepsia

NCT06958952

Dyspepsia Chronic

RECRUITING NA

Effect Of Itopride On Gastric Emptying And Accommodation In Patients With Functional Dyspepsia

NCT01226134

Functional Dyspepsia Gastric Emptying Gastric Accommodation

UNKNOWN NA

Small Volume Simethicone Before Gastroscopy: Any Benefit?

NCT02555228

Lesion of Stomach

COMPLETED PHASE2/PHASE3

Therapeutic Effect of Ursodeoxycholic Acid in Functional Dyspepsia

NCT03004118

Functional Dyspepsia

ACTIVE_NOT_RECRUITING PHASE4

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The prostaglandin system plays an important role in the gastric mucosa to strengthen its resistance against injury. Critically ill patients are at greatest risk of developing stress-related gastric mucosal lesions. Although the levels of prostaglandins in gastric mucosa in patients with stressed animal has been studied, prostaglandin levels in the gastric mucosa in patients with stress ulcer have not been studied and the effect of Prevacid on prostaglandin levels in gastric mucosa from patients with stress ulcer is unknown.

We hypothesize that prostaglandin levels are low in the gastric mucosa in patients with stress ulcer, and Prevacid is an effective agents in increasing prostaglandin levels in the gastric mucosa in stress stress ulcer.

Comparison(s): The prostaglandin levels in patients who treated with Prevacid for stress ulcer, compared to the prostaglandin levels in patients who treated with H2 blocker for stress ulcer.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Stomach Ulcer

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Prevacid

Effect of Prevacid at 8 weeks; EGD(esophagogastroduodenal endoscopy) at day 1 \& EGD at 8 weeks

Group Type EXPERIMENTAL

Prevacid

Intervention Type DRUG

Effect of Prevacid on prostaglandin levels at 8 weeks; EGD (esophagogastroduodenal endoscopy) with biopsy at day 1 \& EGD with biopsy at 8 weeks

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Prevacid

Effect of Prevacid on prostaglandin levels at 8 weeks; EGD (esophagogastroduodenal endoscopy) with biopsy at day 1 \& EGD with biopsy at 8 weeks

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Lansoprazole

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients in ICU with documented gastric stress ulcer by endoscopic examination, including patients with H. Pylori infection;
* Patients have no known ulcer within 8 weeks prior to be admitted to ICU;
* Patients not on any PPI for 4 weeks prior to the study;
* Patients or family be consented for the study.

Exclusion Criteria

* Patients have gastric ulcer within 8 weeks prior to be admitted to ICU;
* Patients have gastric cancer confirmed by pathology;
* Patients on one of the PPIs already;
* Patients on any of the Non-steroidal Antiinflammatory Drugs.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No