Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients

NCT ID: NCT00224055

Last Updated: 2012-03-29

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

89 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-04-30

Study Completion Date

2004-09-30

Brief Summary

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This study compares the effect of Ferrlecit® (a form of intravenous iron) to ferrous sulfate (a form of oral iron) in treating anemia and iron deficiency in chronic kidney disease patients who are not receiving erythropoietic agents (hormones that stimulate the bone marrow to make more red blood cells).

Detailed Description

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Conditions

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Anemia, Iron-Deficiency Kidney Failure, Chronic

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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IV iron

Sodium ferric gluconate

Group Type EXPERIMENTAL

Sodium Ferric Gluconate Complex in Sucrose Injection

Intervention Type DRUG

Sodium Ferric Gluconate Complex in Sucrose Injection (Ferrlecit®), 250 mg IV weekly for 4 weeks

oral iron

ferrous sulfate

Group Type ACTIVE_COMPARATOR

Ferrous sulfate tablets

Intervention Type DRUG

ferrous sulfate, 325 mg oral, three times daily for 6 weeks

Interventions

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Sodium Ferric Gluconate Complex in Sucrose Injection

Sodium Ferric Gluconate Complex in Sucrose Injection (Ferrlecit®), 250 mg IV weekly for 4 weeks

Intervention Type DRUG

Ferrous sulfate tablets

ferrous sulfate, 325 mg oral, three times daily for 6 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Moderate to severe anemia
* Iron deficiency
* Moderate to severe chronic kidney disease

Exclusion Criteria

* Receiving dialysis
* Known sensitivity to Ferrlecit® or any of its components
* Receiving therapy with erythropoietic agent
* Clinically unstable
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Watson Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Naomi Dahl, Pharm.D.

Role: STUDY_DIRECTOR

Watson Laboratories, Inc.

Locations

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Tucson, Arizona, United States

Site Status

Los Angeles, California, United States

Site Status

Palo Alto, California, United States

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San Diego, California, United States

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Hines, Illinois, United States

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Indianapolis, Indiana, United States

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Shreveport, Louisiana, United States

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Baltimore, Maryland, United States

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Springfield, Massachusetts, United States

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Detroit, Michigan, United States

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St Louis, Missouri, United States

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Birmingham, New York, United States

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Mineola, New York, United States

Site Status

New York, New York, United States

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The Bronx, New York, United States

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Chapel Hill, North Carolina, United States

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Cleveland, Ohio, United States

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Philadelphia, Pennsylvania, United States

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Charlotte, South Carolina, United States

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Chattanooga, Tennessee, United States

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Memphis, Tennessee, United States

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Houston, Texas, United States

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Fairfax, Virginia, United States

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San Juan, , Puerto Rico

Site Status

Countries

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United States Puerto Rico

References

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Agarwal R, Rizkala AR, Bastani B, Kaskas MO, Leehey DJ, Besarab A. A randomized controlled trial of oral versus intravenous iron in chronic kidney disease. Am J Nephrol. 2006;26(5):445-54. doi: 10.1159/000096174. Epub 2006 Oct 11.

Reference Type RESULT
PMID: 17035697 (View on PubMed)

Other Identifiers

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FER0202

Identifier Type: -

Identifier Source: org_study_id

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