2 Doses of Ferrlecit Versus Oral Iron to Treat Iron-deficiency Anemia in Peritoneal Dialysis Patients.

NCT ID: NCT00223977

Last Updated: 2013-07-08

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

146 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-12-31

Study Completion Date

2008-02-29

Brief Summary

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This is a phase 3 clinical investigation. Patients who meet the eligibility criteria and provide signed informed consent will be randomized to receive one of two levels of Ferrlecit or oral iron in a 1:1:1 ratio.

Detailed Description

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Conditions

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Iron Deficiency Anemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Sodium ferric gluconate complex 125 mg

125 mg sodium ferric gluconate weekly x 8 weeks

Group Type EXPERIMENTAL

Sodium Ferric Gluconate Complex

Intervention Type DRUG

125 mg weekly x 8 weeks

Sodium ferric gluconate complex 250 mg

250 mg sodium ferric gluconate complex weekly x 4 weeks

Group Type EXPERIMENTAL

Sodium Ferric Gluconate Complex

Intervention Type DRUG

250 mg weekly x 4

Oral iron

325 mg ferrous sulfate three times daily x 8 weeks

Group Type ACTIVE_COMPARATOR

Oral Iron

Intervention Type DRUG

325 mg ferrous sulfate orally three times daily x 8 weeks

Interventions

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Sodium Ferric Gluconate Complex

125 mg weekly x 8 weeks

Intervention Type DRUG

Sodium Ferric Gluconate Complex

250 mg weekly x 4

Intervention Type DRUG

Oral Iron

325 mg ferrous sulfate orally three times daily x 8 weeks

Intervention Type DRUG

Other Intervention Names

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Ferrlecit Ferrlecit

Eligibility Criteria

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Inclusion Criteria

* Male or female, at least 18 years of age.
* Received maintenance peritoneal dialysis therapy for at least 4 weeks.
* Was expected to remain on peritoneal dialysis therapy for duration of study.
* Had predetermined low hemoglobin and transferrin saturation (TSAT) levels.
* Signed patient informed consent.

Exclusion Criteria

* Had a predetermined serum levels of Ferritin and TSAT
* Pregnant or lactating.
* Had a serious concomitant medical disorder incompatible with participation in the study.
* Had a known hypersensitivity to Ferrlecit or any of its components.
* Unable to cooperate or comply with the protocol.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Watson Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gary Hoel, RPh, PhD

Role: STUDY_CHAIR

Watson Pharmaceuticals

Locations

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Birmingham, Alabama, United States

Site Status

Mesa, Arizona, United States

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Los Angeles, California, United States

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Torrance, California, United States

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New Haven, Connecticut, United States

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Evanston, Illinois, United States

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Shreveport, Louisiana, United States

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Springfield, Massachusetts, United States

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Worcester, Massachusetts, United States

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Royal Oak, Michigan, United States

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St Louis, Missouri, United States

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New York, New York, United States

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Chapel Hill, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Tulsa, Oklahoma, United States

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Philadelphia, Pennsylvania, United States

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Sioux Falls, South Dakota, United States

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Dallas, Texas, United States

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Richmond, Virginia, United States

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Sofia, , Bulgaria

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Varna, , Bulgaria

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Kelowna, , Canada

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Kitchener, , Canada

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London, , Canada

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Scarborough, , Canada

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Toronto, , Canada

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Zagreb, , Croatia

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Bangalore, , India

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Chandigarh, , India

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Chennai, , India

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Hyderabad, , India

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Lucknow, , India

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Mahīm, , India

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New Delhi, , India

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Col. Toriello Guerra, , Mexico

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Durango, , Mexico

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Mexico City, , Mexico

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Monterrey, , Mexico

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Tlalpan, , Mexico

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Zapopan, , Mexico

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Osijek, , Poland

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Moscow, , Russia

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Saint Petersburg, , Russia

Site Status

Countries

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United States Bulgaria Canada Croatia India Mexico Poland Russia

Other Identifiers

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FR03001

Identifier Type: -

Identifier Source: org_study_id

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